IMPC phenotypes (gene matching)
C57BL/6N-Lmnb1tm1c(EUCOMM)Wtsi/WtsiH
| Status | Available to order |
| EMMA ID | EM:10615 |
| Citation information | RRID:IMSR_EM:10615 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Lmnb1tm1c(EUCOMM)Wtsi/WtsiH |
| Alternative name | EPD0070_1_G07 |
| Strain type | Targeted Mutant Strains : Targeted Conditional |
| Allele/Transgene symbol | Lmnb1tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Lmnb1 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This line originates from EUCOMM ES clone EPD0070_1_G07, after breeding with a Flp recombinase deleter line to convert the original targeted allele tm1a (knock-out first allele) into a conditional allele tm1c. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6NTac males |
| Breeding at archiving centre | This mutation was generated on a coisogenic C57BL/6NTac background |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant primary microcephaly / Orphanet_2514
- Adult-onset autosomal dominant leukodystrophy / Orphanet_99027
MGI phenotypes (gene matching)
- delayed bone ossification / MGI
- scoliosis / MGI
- decreased circulating calcium level / MGI
- decreased cell proliferation / MGI
- microcephaly / MGI
- abnormal cranium morphology / MGI
- thin diaphragm muscle / MGI
- decreased brain size / MGI
- abnormal stratification in cerebral cortex / MGI
- abnormal lung morphology / MGI
- abnormal lung development / MGI
- absent pulmonary alveoli / MGI
- decreased body weight / MGI
- decreased embryo size / MGI
- respiratory failure / MGI
- abnormal pulmonary alveolus morphology / MGI
- abnormal neuron morphology / MGI
- decreased circulating alkaline phosphatase level / MGI
- abnormal thoracic vertebrae morphology / MGI
- abnormal cell nucleus morphology / MGI
- abnormal coronal suture morphology / MGI
- abnormal sagittal suture morphology / MGI
- decreased fetal size / MGI
- abnormal neuronal precursor proliferation / MGI
- abnormal cell differentiation / MGI
- increased mean corpuscular hemoglobin / MGI
- abnormal neuronal migration / MGI
- impaired lung alveolus development / MGI
- neonatal lethality, complete penetrance / MGI
- abnormal phrenic nerve innervation pattern to diaphragm / MGI
- decreased midbrain size / MGI
- flat head / MGI