C57BL/6-Tg(Kit*)7Mpel/Cnrm
| Status | Available to order |
| EMMA ID | EM:10644 |
| International strain name | C57BL/6-Tg(Kit*)7Mpel/Cnrm |
| Alternative name | c-KitTgD814Y/C57BL/6 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Kit*)7Mpel |
| Gene/Transgene symbol | Tg(Kit*)7Mpel |
Information from provider
| Provider | Manuela Pellegrini |
| Provider affiliation | CNR-IBCN |
| Genetic information | BAC RP23-309C11, containing c-Kit genome sequence was engineered substituting the G to T 2468 to generate c-Kit TgD814Y transgenic mice. |
| Phenotypic information | Homozygous:Transgenic mice expressed c-Kit receptor 2.5-fold higher when compared to control mice and the receptor was constitutively activated in cerebellum, testis and heart. Mice did not show evident phenotypes in physiological conditions.Heterozygous:Transgenic mice expressed c-Kit receptor 2.5-fold higher when compared to control mice and the receptor was constitutively activated in cerebellum, testis and heart. Mice did not show evident phenotypes in physiological conditions. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |