B6(Cg)-Atm1Brd Hdctm1c(EUCOMM)Hmgu/Kctt

Status

Available to order

EMMA IDEM:10674
Citation informationRRID:IMSR_EM:10674 

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International strain nameB6(Cg)-Atm1Brd Hdctm1c(EUCOMM)Hmgu/Kctt
Alternative nameHdctm1c(EUCOMM)Hmgu
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolHdctm1c(EUCOMM)Hmgu
Gene/Transgene symbolHdc

Information from provider

ProviderOlov Andersson
Provider affiliationCell and Molecular Biology, Karolinska Institutet
Additional ownersee attached MTA from EUCOMM
Genetic informationHdc conditional tm1c allele generated by the following ES cells: Hdctm1a(EUCOMM)Hmgu, clone line JM8A3.N1. The generated mice were then crossed with the B6.Cg-Tg(ACTFLP-L)Dym flp recombinase-deleter strain, which was backcrossed on a C57BL/6J background (N11). We want to freeze down the tm1c allele after crossing with flp-deleter strain.
Phenotypic informationHomozygous:
None. The floxed Hdc line was crossed with Pdx1-cre (pancreatic cre recombinase driver) and no pancreatic phenotype was detected.

Heterozygous:
None. The floxed Hdc line was crossed with Pdx1-cre (pancreatic cre recombinase driver) and no pancreatic phenotype was detected.
Breeding historyOriginally C57BL/6N and then maintained on C57BL/6J.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden
Animals used for archivingheterozygous C57BL/6N males

Disease and phenotype information

MGI phenotypes (gene matching)
  • increased brown adipose tissue amount / MGI
  • increased white adipose tissue amount / MGI
  • decreased mast cell number / MGI
  • abnormal mast cell morphology / MGI
  • decreased mast cell protease storage / MGI
  • decreased mast cell histamine storage / MGI
  • abnormal substantia nigra morphology / MGI
  • obese / MGI
  • increased anxiety-related response / MGI
  • decreased exploration in new environment / MGI
  • abnormal spatial learning / MGI
  • increased dopamine level / MGI
  • increased thermal nociceptive threshold / MGI
  • abnormal learning/memory/conditioning / MGI
  • increased circulating insulin level / MGI
  • abnormal brain morphology / MGI
  • abnormal mechanical nociception / MGI
  • abnormal passive avoidance behavior / MGI
  • no phenotypic analysis / MGI
  • abnormal striatum morphology / MGI
  • impaired glucose tolerance / MGI
  • behavior/neurological phenotype / MGI
  • abnormal energy expenditure / MGI
  • increased susceptibility to weight gain / MGI
  • increased circulating leptin level / MGI
  • increased chemical nociceptive threshold / MGI
  • increased white fat cell size / MGI
  • decreased prepulse inhibition / MGI
  • increased epididymal fat pad weight / MGI
  • increased interscapular fat pad weight / MGI
  • abnormal behavioral response to amphetamine / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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