C57BL/6N-A^tm1Brd Tmprss6^{tm1a(EUCOMM)Wtsi}/Ics

Status	Available to order
EMMA ID	EM:10677
Citation information	RRID:IMSR_EM:10677 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-A^tm1Brd Tmprss6^{tm1a(EUCOMM)Wtsi}/Ics
Alternative name	EPD0453_1_B07
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Tmprss6^{tm1a(EUCOMM)Wtsi}
Gene/Transgene symbol	Tmprss6
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	This mouse line originates from EUCOMM ES clone EPD0453_1_B07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France
Animals used for archiving	heterozygous C57BL/6N males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IRIDA syndrome / Orphanet_209981

IMPC phenotypes (gene matching)

short tibia / IMPC
decreased prepulse inhibition / IMPC
decreased mean corpuscular hemoglobin concentration / IMPC
abnormal coat/ hair morphology / IMPC
abnormal coat/hair pigmentation / IMPC
decreased exploration in new environment / IMPC
abnormal skin morphology / IMPC
decreased locomotor activity / IMPC
increased heart weight / IMPC
increased fasting circulating glucose level / IMPC
abnormal coat appearance / IMPC
increased Ly6C-positive mature NK cell number / IMPC
decreased NK cell number / IMPC
increased circulating calcium level / IMPC
decreased mean corpuscular hemoglobin / IMPC
increased CD11b-high dendritic cell number / IMPC
decreased mean corpuscular volume / IMPC
decreased hemoglobin content / IMPC
increased effector memory CD8-positive, alpha-beta T cell number / IMPC
immune system phenotype / IMPC
decreased CD8-positive, alpha-beta T cell number / IMPC
decreased hematocrit / IMPC

MGI phenotypes (gene matching)

decreased hematocrit / MGI
extramedullary hematopoiesis / MGI
abnormal hair follicle morphology / MGI
alopecia / MGI
sparse hair / MGI
focal hair loss / MGI
decreased body size / MGI
anemia / MGI
abnormal intestinal mineral absorption / MGI
postnatal growth retardation / MGI
abnormal iron level / MGI
reduced female fertility / MGI
female infertility / MGI
abnormal erythrocyte morphology / MGI
decreased mean corpuscular volume / MGI
reticulocytosis / MGI
anisopoikilocytosis / MGI
microcytic anemia / MGI
microcytosis / MGI
decreased hemoglobin content / MGI
decreased erythrocyte cell number / MGI
abnormal ovary development / MGI
pallor / MGI
maternal effect / MGI
decreased circulating iron level / MGI
increased spleen weight / MGI
hematopoietic system phenotype / MGI
decreased mean corpuscular hemoglobin / MGI
abnormal iron homeostasis / MGI
decreased mean corpuscular hemoglobin concentration / MGI
decreased liver iron level / MGI
decreased spleen iron level / MGI
progressive hair loss / MGI
increased red blood cell distribution width / MGI
abnormal hair follicle infundibulum morphology / MGI
thin hair follicle outer root sheath / MGI
mortality/aging / MGI
postnatal lethality, incomplete penetrance / MGI
increased circulating unsaturated transferrin level / MGI
decreased pancreas iron level / MGI
decreased heart iron level / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.
Not found what you were looking for? Search here for other strains available from EMMA.

C57BL/6N-Atm1Brd Tmprss6tm1a(EUCOMM)Wtsi/Ics