B6.129-Flt4tm1Ali/Oulu

Status

Available to order

EMMA IDEM:10724
Citation informationRRID:IMSR_EM:10724 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129-Flt4tm1Ali/Oulu
Alternative nameVEGFR3/LacZ
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolFlt4tm1Ali
Gene/Transgene symbolFlt4

Information from provider

ProviderKari Alitalo
Provider affiliationTranslational Cancer Biology Research Program; Institute of Biomedicine, University of Helsinki
Genetic informationVegfr3 has been replaced with LacZ-insert.
Phenotypic informationHomozygous:
Homozygous mice die around E10-E11 because of the cardiovascular defects

Heterozygous:
No obvious phenotype
Breeding history10 backcrosses to C57BL/6
References
  • Cardiovascular failure in mouse embryos deficient in VEGF receptor-3.;Dumont D J, Jussila L, Taipale J, Lymboussaki A, Mustonen T, Pajusola K, Breitman M, Alitalo K, ;1998;Science (New York, N.Y.);282;946-9; 9794766
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • embryonic growth retardation / MGI
  • prenatal lethality, complete penetrance / MGI
  • abnormal vascular development / MGI
  • pale yolk sac / MGI
  • pericardial edema / MGI
  • abnormal vitelline vascular remodeling / MGI
  • abnormal anterior cardinal vein morphology / MGI
  • abnormal dorsal aorta morphology / MGI
  • hemopericardium / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • abnormal perineural vascular plexus morphology / MGI
  • absent lymphatic vessels / MGI
MGI phenotypes (gene matching)
  • abnormal adipose tissue distribution / MGI
  • abnormal vascular development / MGI
  • abnormal intestine morphology / MGI
  • abnormal liver morphology / MGI
  • thick dermal layer / MGI
  • pale yolk sac / MGI
  • edema / MGI
  • pericardial edema / MGI
  • abnormal lymphatic vessel morphology / MGI
  • postnatal lethality / MGI
  • no abnormal phenotype detected / MGI
  • hydrops fetalis / MGI
  • no phenotypic analysis / MGI
  • extremity edema / MGI
  • lymphedema / MGI
  • abnormal lymph circulation / MGI
  • embryonic growth retardation / MGI
  • abnormal vitelline vascular remodeling / MGI
  • abnormal anterior cardinal vein morphology / MGI
  • abnormal dorsal aorta morphology / MGI
  • hemopericardium / MGI
  • cardiovascular system phenotype / MGI
  • reproductive system phenotype / MGI
  • abnormal lymphangiogenesis / MGI
  • absent lymphatic vessels / MGI
  • neonatal lethality, complete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • chylous ascites / MGI
  • abnormal perineural vascular plexus morphology / MGI

Literature references

  • Cardiovascular failure in mouse embryos deficient in VEGF receptor-3.;Dumont D J, Jussila L, Taipale J, Lymboussaki A, Mustonen T, Pajusola K, Breitman M, Alitalo K, ;1998;Science (New York, N.Y.);282;946-9; 9794766

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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