MGI phenotypes (allele matching)
STOCK Vegfctm1Ali/Oulu
| Status | Available to order |
| EMMA ID | EM:10734 |
| International strain name | STOCK Vegfctm1Ali/Oulu |
| Alternative name | VEGFC/LacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Vegfctm1Ali, |
| Gene/Transgene symbol | Vegfc |
Information from provider
| Provider | Kari Alitalo |
| Provider affiliation | Translational Cancer Biology Research Program; Institute of Biomedicine, University of Helsinki |
| Genetic information | Vegfc has been replaced with a lacZ and neo cassette inserted by homologous recombination. |
| Phenotypic information | Homozygous:Not viable, die around E16-E17.Heterozygous:Those heterozygous mice that survive until weaning are viable and fertile. Surviving rate to this point is relatively poor and background dependent. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous 0 |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Milroy disease / Orphanet_79452
- Congenital primary lymphedema of Gordon / Orphanet_569821
Literature references
- Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.;Karkkainen Marika J, Haiko Paula, Sainio Kirsi, Partanen Juha, Taipale Jussi, Petrova Tatiana V, Jeltsch Michael, Jackson David G, Talikka Marja, Rauvala Heikki, Betsholtz Christer, Alitalo Kari, ;2004;Nature immunology;5;74-80; 14634646