C57BL/6N-Atm1Brd Cog6tm1a(EUCOMM)Wtsi/WtsiFlmg

Status

Available to order

EMMA IDEM:10819
International strain nameC57BL/6N-Atm1Brd Cog6tm1a(EUCOMM)Wtsi/WtsiFlmg
Alternative nameEPD0609_4_H05
Strain typeTargeted Mutant Strains
Allele/Transgene symbolCog6tm1a(EUCOMM)Wtsi,
Gene/Transgene symbolCog6
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0609_4_H05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreB.S.R.C. Alexander Fleming, Vari, Greece

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • increased monocyte cell number / IMPC
  • increased granulocyte number / IMPC
  • abnormal cornea morphology / IMPC
  • abnormal coat/hair pigmentation / IMPC
  • increased mean platelet volume / IMPC
  • decreased hemoglobin content / IMPC
  • decreased erythrocyte cell number / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • vertebral transformation / IMPC
  • abnormal bone structure / IMPC
  • increased eosinophil cell number / IMPC
  • increased B cell number / IMPC
  • decreased T cell number / IMPC
  • increased circulating total protein level / IMPC
  • decreased NK T cell number / IMPC
  • decreased NK cell number / IMPC
  • increased CD4-positive, alpha beta T cell number / IMPC
  • decreased CD4-positive, alpha beta T cell number / IMPC
  • decreased CD8-positive, alpha-beta T cell number / IMPC
  • increased plasma cell number / IMPC
  • increased follicular B cell number / IMPC
  • decreased marginal zone B cell number / IMPC
  • increased B-2 B cell number / IMPC
  • increased gamma-delta T cell number / IMPC
  • increased circulating amylase level / IMPC
  • decreased transitional stage T2 B cell number / IMPC
  • increased red blood cell distribution width / IMPC
  • decreased bone mineral content / IMPC
  • increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • increased effector memory CD4-positive, alpha-beta T cell number / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • decreased alpha-beta T cell number / IMPC
  • increased KLRG1-positive NK cell number / IMPC
  • increased Ly6C high monocyte number / IMPC
  • increased KLRG1+ CD8 alpha beta T cell number / IMPC
  • increased KLRG1+ CD4 alpha beta T cell number / IMPC
  • decreased memory-marker gamma-delta T cell number / IMPC
  • increased memory-marker gamma-delta T cell number / IMPC
  • increased CD5-positive gamma-delta T cell number / IMPC
  • decreased memory-marker NK cell number / IMPC
  • increased memory-marker NK cell number / IMPC
  • increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • decreased CD8-positive, naive alpha-beta T cell number / IMPC
  • increased CD4-negative NK T cell number / IMPC
  • decreased memory-marker CD4-negative NK T cell number / IMPC
  • decreased CD4-positive NK T cell number / IMPC
  • decreased memory-marker CD4-positive NK T cell number / IMPC
  • decreased Ly6C-positive immature NK cell number / IMPC
  • decreased Ly6C-positive mature NK cell number / IMPC
  • decreased T-helper cell number / IMPC
  • increased effector memory T-helper cell number / IMPC
  • increased KLRG1-positive T-helper cell number / IMPC
MGI phenotypes (allele matching)
  • intracerebral hemorrhage / MGI
  • fusion of vertebral arches / MGI
  • abnormal inferior vena cava morphology / MGI
  • abnormal liver vasculature morphology / MGI
  • muscular ventricular septal defect / MGI
  • abnormal inferior vena cava valve morphology / MGI
  • dual inferior vena cava / MGI
  • thin hypoglossal nerve / MGI
  • abnormal vitelline vein connection / MGI
  • abnormal ductus venosus valve morphology / MGI
  • abnormal coronary sinus connection / MGI
  • abnormal vertebral artery topology / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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