- increased mean corpuscular volume / IMPC
- increased basophil cell number / IMPC
- short tibia / IMPC
- decreased circulating alkaline phosphatase level / IMPC
- decreased heart rate / IMPC
- prolonged RR interval / IMPC
- preweaning lethality, complete penetrance / IMPC
- embryonic lethality prior to organogenesis / IMPC
C57BL/6NTac-Gcshem1(IMPC)H/H
Status | Available to order |
EMMA ID | EM:10851 |
International strain name | C57BL/6NTac-Gcshem1(IMPC)H/H |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Gcshem1(IMPC)H |
Gene/Transgene symbol | Gcsh |
Information from provider
Provider | MRC, Medical Research Council |
Provider affiliation | Mammalian Genetics Unit, Mary Lyon Centre at MRC Harwell |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Atypical glycine encephalopathy / Orphanet_289863
- Neonatal glycine encephalopathy / Orphanet_289857
- Infantile glycine encephalopathy / Orphanet_289860
IMPC phenotypes (allele matching)
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