B6JNimr.129S7-Dp(10Prmt2-Pdxk)2Yey/YeyH
| Status | Available to order |
| EMMA ID | EM:10969 |
| International strain name | B6JNimr.129S7-Dp(10Prmt2-Pdxk)2Yey/YeyH |
| Alternative name | C57BL/6JNimr.129-Dp(10Prmt2-Pdxk)2Yey/NimrH |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Dp(10Prmt2-Pdxk)2Yey, |
| Gene/Transgene symbol | Dp(10Prmt2-Pdxk)2Yey |
Information from provider
| Provider | Eugene Yu |
| Provider affiliation | Cancer Genetics and Genomics, Roswell Park Cancer Institute |
| Genetic information | Strain carries a duplication spanning Prmt2 to Pdxk on Chr10 - approx 2.3Mb in size. This region is syntenic with the distal part of human 21q22.3. The duplication was cre recombinase-mediated via insertion of loxP sites. |
| Phenotypic information | Homozygous:Not knownHeterozygous:In conjunction with other duplications that carry the homologous genes to those carried on Hsa21, this provides a valuable mouse model of human Down's syndrome. |
| Breeding history | Generated on 129S7/SvEvBrd-Hprtb-m2 ES cell line, maintained by backcrossing to C57BL/6JNimr. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6JNimr |
| Breeding at archiving centre | C57BL/6JNimr background |
Literature references
- A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions.;Yu Tao, Li Zhongyou, Jia Zhengping, Clapcote Steven J, Liu Chunhong, Li Shaomin, Asrar Suhail, Pao Annie, Chen Rongqing, Fan Ni, Carattini-Rivera Sandra, Bechard Allison R, Spring Shoshana, Henkelman R Mark, Stoica George, Matsui Sei-Ichi, Nowak Norma J, Roder John C, Chen Chu, Bradley Allan, Yu Y Eugene, ;2010;Human molecular genetics;19;2780-91; 20442137