B6JNimr.129S7-Dp(17Abcg1-Rrp1b)3Yey/YeyH

Status	Available to order
EMMA ID	EM:10970
Citation information	RRID:IMSR_EM:10970 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6JNimr.129S7-Dp(17Abcg1-Rrp1b)3Yey/YeyH
Alternative name	C57BL/6JNimr.129-Dp(17Abcg1-Rrp1b)3Yey/NimrH
Strain type	Targeted Mutant Strains : Other targeted
Allele/Transgene symbol	Dp(17Abcg1-Rrp1b)3Yey
Gene/Transgene symbol	Dp(17Abcg1-Rrp1b)3Yey

Information from provider

Provider	Eugene Yu
Provider affiliation	Cancer Genetics and Genomics, Roswell Park Cancer Institute
Genetic information	Strain carries a duplication spanning Abcg1 to Rrp1b on Chr17 - approx. 1.1Mb in size. This region is syntenic with the distal part of human 21q22.3. The duplication was cre recombinase-mediated via insertion of loxP sites.
Phenotypic information	Homozygous: Not known. Heterozygous: In conjunction with other duplications that carry the homologous genes to those carried on Hsa21, this provides a valuable mouse model of human Down's syndrome.
Breeding history	Generated on 129S7/SvEvBrd-Hprt^b-m2 ES cell line.
References	A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions.;Yu Tao, Li Zhongyou, Jia Zhengping, Clapcote Steven J, Liu Chunhong, Li Shaomin, Asrar Suhail, Pao Annie, Chen Rongqing, Fan Ni, Carattini-Rivera Sandra, Bechard Allison R, Spring Shoshana, Henkelman R Mark, Stoica George, Matsui Sei-Ichi, Nowak Norma J, Roder John C, Chen Chu, Bradley Allan, Yu Y Eugene, ;2010;Human molecular genetics;19;2780-91; 20442137
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archiving	heterozygous C57BL/6JNimr males, wild-type C57BL/6JNimr females
Breeding at archiving centre	C57BL/6JNimr background

Literature references

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions.;Yu Tao, Li Zhongyou, Jia Zhengping, Clapcote Steven J, Liu Chunhong, Li Shaomin, Asrar Suhail, Pao Annie, Chen Rongqing, Fan Ni, Carattini-Rivera Sandra, Bechard Allison R, Spring Shoshana, Henkelman R Mark, Stoica George, Matsui Sei-Ichi, Nowak Norma J, Roder John C, Chen Chu, Bradley Allan, Yu Y Eugene, ;2010;Human molecular genetics;19;2780-91; 20442137

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
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