| Status | Available to order |
| EMMA ID | EM:11118 |
| Citation information | RRID:IMSR_EM:11118 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6JD2(Cg)-Sox2tm#Asim/Cnrm |
| Alternative name | Sox2deltaOBS |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Sox2tm#Asim |
| Gene/Transgene symbol | Sox2 |
| Provider | Antonio Simeone |
| Provider affiliation | IGB-CNR |
| Genetic information | Mutagenesis of seven Otx2 binding sites (OBS) on Sox2 promoter in the region spanning to -4033 to -2408 respect to methionine 1. The mutations are generated on the basis of chip-seq data that identify a region of Sox2 promoter spanning -4033 to -2408, respect to methionine 1, containing seven putative binding sites of Otx2 protein. These binding sites were abolished by PCR mutagenesis, the region cloned into targeting vector and introduced in ES via homologous recombination. |
| Phenotypic information | Homozygous:Mice are viable and fertile. The homozygous mice are viable and fertile, but they have never been studied at early embryo stage and during development.Heterozygous:Mice are viable and fertile. |
| Breeding history | The mice are maintained in a mixed background B6D2 (C57BL/6J x DBA/2) |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Orphanet associated rare diseases, based on orthologous gene matching
