MGI phenotypes (allele matching)
B6.129X1(Cg)-Esr1tm1.1Gust/Kctt
| Status | Available to order |
| EMMA ID | EM:11180 |
| International strain name | B6.129X1(Cg)-Esr1tm1.1Gust/Kctt |
| Alternative name | B6.129X1-Esr1tm1.1Gust. |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Esr1tm1.1Gust, |
| Gene/Transgene symbol | Esr1 |
Information from provider
| Provider | Per Antonson |
| Provider affiliation | Department of Biosciences and Nutrition, Karolinska Institutet |
| Genetic information | Global knockout of Esr1. Floxed exon 3 (B6.129X1-Esr1tm1Gust; EMMA strain EM:11179) deleted by Cre expression in mice. |
| Phenotypic information | Homozygous:Infertility in male and female mice.Heterozygous:none |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Estrogen resistance syndrome / Orphanet_785
Literature references
- Generation of ERα-floxed and knockout mice using the Cre/LoxP system.;Antonson P, Omoto Y, Humire P, Gustafsson J-Å, ;2012;Biochemical and biophysical research communications;424;710-6; 22800760
- Estrogen Receptor-α Knockout Mice.;Antonson Per, Humire Patricia, Gustafsson Jan-Åke, ;2016;Methods in molecular biology (Clifton, N.J.);1366;425-430; 26585154