B6;129-Hsp90ab1Gt(pGT1.8geo)1Pgr/Cnrm

Status

Available to order

EMMA IDEM:00112
International strain nameB6;129-Hsp90ab1Gt(pGT1.8geo)1Pgr/Cnrm
Alternative nameHSP90b-gt
Strain typeGene-trap
Allele/Transgene symbolHsp90ab1Gt(pGT1.8geo)1Pgr,
Gene/Transgene symbolHsp90ab1

Information from provider

ProviderPeter Gruss
Provider affiliationMax Planck Inst. Biophysical Chemistry
Genetic informationInsertion of the pGT1.8 geo construct in exon 9 of the Hsp90ab1 (Hspcb) locus.
Phenotypic informationMutant embryos fail to form a placental labyrinth and die at E10.5.
References
  • Mice lacking HSP90beta fail to develop a placental labyrinth.;Voss A K, Thomas T, Gruss P, ;2000;Development (Cambridge, England);127;1-11; 10654595

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal placenta labyrinth morphology / MGI
  • abnormal placenta vasculature / MGI
  • absent heartbeat / MGI
  • abnormal trophoblast layer morphology / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • embryo tissue necrosis / MGI

Literature references

  • Mice lacking HSP90beta fail to develop a placental labyrinth.;Voss A K, Thomas T, Gruss P, ;2000;Development (Cambridge, England);127;1-11; 10654595

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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