B6.129P2-Igh-Jtm1Cgn/CgnCnrm

Status

Available to order

EMMA IDEM:01127
International strain nameB6.129P2-Igh-Jtm1Cgn/CgnCnrm
Alternative nameIgh-JHT
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIgh-Jtm1Cgn,
Gene/Transgene symbolIgh-J

Information from provider

ProviderKlaus Rajewsky
Provider affiliationCBR Institute for Biomedical Research, Immune Disease Institute
Genetic informationDeletion of JH1, 2, 3 and 4 elements including the DQ52 gene segment and the heavy chain enhancer.
Phenotypic informationB cell deficiency. Mice are immunosuppressed and show an impaired pathogen defense.
Breeding historyBackcrossed to C57BL/6 (more than 10 generations)
References
  • Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting.;Gu H, Zou Y R, Rajewsky K, ;1993;Cell;73;1155-64; 8513499

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal B cell differentiation / MGI
  • arrested B cell differentiation / MGI
  • absent mature B cells / MGI

Literature references

  • Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting.;Gu H, Zou Y R, Rajewsky K, ;1993;Cell;73;1155-64; 8513499

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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