B6.129P2-Igh-Jtm1Cgn/CgnCnrm
Status | Available to order |
EMMA ID | EM:01127 |
International strain name | B6.129P2-Igh-Jtm1Cgn/CgnCnrm |
Alternative name | Igh-JHT |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Igh-Jtm1Cgn, |
Gene/Transgene symbol | Igh-J |
Information from provider
Provider | Klaus Rajewsky |
Provider affiliation | CBR Institute for Biomedical Research, Immune Disease Institute |
Genetic information | Deletion of JH1, 2, 3 and 4 elements including the DQ52 gene segment and the heavy chain enhancer. |
Phenotypic information | B cell deficiency. Mice are immunosuppressed and show an impaired pathogen defense. |
Breeding history | Backcrossed to C57BL/6 (more than 10 generations) |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting.;Gu H, Zou Y R, Rajewsky K, ;1993;Cell;73;1155-64; 8513499
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