B6;D2-Tg(Cd4-cre)1Cwi/CwiCnrm

Status	Available to order
EMMA ID	EM:01139
Citation information	RRID:IMSR_EM:01139 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6;D2-Tg(Cd4-cre)1Cwi/CwiCnrm
Alternative name	CD4-Cre
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Cd4-cre)1Cwi
Gene/Transgene symbol	Tg(Cd4-cre)1Cwi

Information from provider

Provider	Chris Wilson
Provider affiliation	Department of Immunology, University of Washington, Dept. Immunology
Genetic information	CD4-cre mice specifically express the P1 bacteriophage cre recombinase in T-cells.
Phenotypic information	CD4-cre mice have been shown to efficiently delete loxP-flanked genes in the T-cell lineage.
Breeding history	(C57BL/6 x DBA/2)F2 background; backcrossed to C57BL/6 (2-3 generations).
References	A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.;Lee P P, Fitzpatrick D R, Beard C, Jessup H K, Lehar S, Makar K W, Pérez-Melgosa M, Sweetser M T, Schlissel M S, Nguyen S, Cherry S R, Tsai J H, Tucker S M, Weaver W M, Kelso A, Jaenisch R, Wilson C B, ;2001;Immunity;15;763-74; 11728338

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.;Lee P P, Fitzpatrick D R, Beard C, Jessup H K, Lehar S, Makar K W, Pérez-Melgosa M, Sweetser M T, Schlissel M S, Nguyen S, Cherry S R, Tsai J H, Tucker S M, Weaver W M, Kelso A, Jaenisch R, Wilson C B, ;2001;Immunity;15;763-74; 11728338
MYC deficiency impairs the development of effector/memory T lymphocytes.;Nozais Mathis, Loosveld Marie, Pankaew Saran, Grosjean Clémence, Gentil Noémie, Quessada Julie, Nadel Bertrand, Mionnet Cyrille, Potier Delphine, Payet-Bornet Dominique, ;2021;iScience;24;102761; 34258568
Isolation and enrichment of mouse splenic T cells for ex vivo and in vivo T cell receptor stimulation assays.;Grosjean Clémence, Quessada Julie, Nozais Mathis, Loosveld Marie, Payet-Bornet Dominique, Mionnet Cyrille, ;2021;STAR protocols;2;100961; 34825221
Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity.;Xiao Yin, Qureischi Musga, Dietz Lena, Vaeth Martin, Vallabhapurapu Subrahmanya D, Klein-Hessling Stefan, Klein Matthias, Liang Chunguang, König Anika, Serfling Edgar, Mottok Anja, Bopp Tobias, Rosenwald Andreas, Buttmann Mathias, Berberich Ingolf, Beilhack Andreas, Berberich-Siebelt Friederike, ;2021;The Journal of experimental medicine;218;101041; 32986812
PI3-Kinase p110α Deficiency Modulates T Cell Homeostasis and Function and Attenuates Experimental Allergic Encephalitis in Mature Mice.;Rojo José M, Montes-Casado María, Aragoneses-Fenoll Laura, Ojeda Gloria, Dianzani Umberto, Portolés Pilar, ;2021;International journal of molecular sciences;22;16258-63; 34445401
The PI-3-Kinase P110α Catalytic Subunit of T Lymphocytes Modulates Collagen-Induced Arthritis.;Montes-Casado María, Ojeda Gloria, Criado Gabriel, Rojo José M, Portolés Pilar, ;2021;International journal of molecular sciences;22;e102066; 34203838
Multiplexed single-cell RNA-sequencing of mouse thymic and splenic samples.;Pankaew Saran, Grosjean Clémence, Quessada Julie, Loosveld Marie, Potier Delphine, Payet-Bornet Dominique, Nozais Mathis, ;2021;STAR protocols;3;2079-83; 36475567
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.;Vaeth Martin, Schliesser Ulrike, Müller Gerd, Reissig Sonja, Satoh Kazuki, Tuettenberg Andrea, Jonuleit Helmut, Waisman Ari, Müller Martin R, Serfling Edgar, Sawitzki Birgit S, Berberich-Siebelt Friederike, ;2012;Proceedings of the National Academy of Sciences of the United States of America;109;332; 22991461
T-cell autophagy deficiency increases mortality and suppresses immune responses after sepsis.;Lin Chih-Wen, Lo Steven, Hsu Chin, Hsieh Chi-Hsun, Chang Ya-Fang, Hou Bao-Sheng, Kao Ying-Hsien, Lin Chih-Che, Yu Ming-Lung, Yuan Shyng-Shiou, Hsieh Ya-Ching, ;2014;PloS one;9;; 25029098
Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27.;Young Andrew, Linehan Eimear, Hams Emily, O'Hara Hall Aisling C, McClurg Angela, Johnston James A, Hunter Christopher A, Fallon Padraic G, Fitzgerald Denise C, ;2012;Journal of immunology (Baltimore, Md. : 1950);189;; 22837488
T-Cell-Specific Loss of the PI-3-Kinase p110α Catalytic Subunit Results in Enhanced Cytokine Production and Antitumor Response.;Aragoneses-Fenoll Laura, Ojeda Gloria, Montes-Casado María, Acosta-Ampudia Yeny, Dianzani Umberto, Portolés Pilar, Rojo José M, ;2018;Frontiers in immunology;9;; 29535720

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