B6.129P2-Pik3catm3Bvan/Orl

Status

Available to order

EMMA IDEM:11394
Citation informationRRID:IMSR_EM:11394 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129P2-Pik3catm3Bvan/Orl
Alternative nameB6.129P2-Pik3catm1Bvan/J
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolPik3catm3Bvan
Gene/Transgene symbolPik3ca

Information from provider

ProviderBart Vanhaesebroeck
Provider affiliationUCL Cancer Institute, University College London
Additional ownerthe University of Edinburgh
Genetic informationExons 18 and 19 of the Pik3ca (PIK3CA/p110alpha) gene are flanked by loxP sites; backcrossed to C57BL/6J background.
Phenotypic informationHomozygous:
Mice are phenotypically normal.

Heterozygous:
Mice are phenotypically normal.
Breeding historyBackcrossed to C57BL/6J for more than 10 generations.
References
  • Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.;Graupera Mariona, Guillermet-Guibert Julie, Foukas Lazaros C, Phng Li-Kun, Cain Robert J, Salpekar Ashreena, Pearce Wayne, Meek Stephen, Millan Jaime, Cutillas Pedro R, Smith Andrew J H, Ridley Anne J, Ruhrberg Christiana, Gerhardt Holger, Vanhaesebroeck Bart, ;2008;Nature;453;662-6; 18449193
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • vasculature congestion / MGI
  • abnormal vascular development / MGI
  • abnormal angiogenesis / MGI
  • decreased cell proliferation / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • polyphagia / MGI
  • internal hemorrhage / MGI
  • abnormal somite development / MGI
  • decreased embryo size / MGI
  • pale yolk sac / MGI
  • embryonic growth arrest / MGI
  • postnatal growth retardation / MGI
  • abnormal lymphatic vessel morphology / MGI
  • hemorrhage / MGI
  • neoplasm / MGI
  • increased circulating insulin level / MGI
  • abnormal retinal vasculature morphology / MGI
  • no phenotypic analysis / MGI
  • abnormal vitelline vasculature morphology / MGI
  • increased pancreatic beta cell number / MGI
  • decreased lean body mass / MGI
  • abnormal endocardium morphology / MGI
  • embryonic growth retardation / MGI
  • abnormal vitelline vascular remodeling / MGI
  • fetal growth retardation / MGI
  • decreased incidence of tumors by chemical induction / MGI
  • abnormal anterior cardinal vein morphology / MGI
  • abnormal dorsal aorta morphology / MGI
  • decreased skeletal muscle mass / MGI
  • abnormal brain vasculature morphology / MGI
  • impaired glucose tolerance / MGI
  • insulin resistance / MGI
  • abnormal cell physiology / MGI
  • increased circulating leptin level / MGI
  • increased fat cell size / MGI
  • abnormal lymphangiogenesis / MGI
  • mortality/aging / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • chylous ascites / MGI
  • abnormal intersomitic vessel morphology / MGI
  • abnormal perineural vascular plexus morphology / MGI

Literature references

  • Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.;Graupera Mariona, Guillermet-Guibert Julie, Foukas Lazaros C, Phng Li-Kun, Cain Robert J, Salpekar Ashreena, Pearce Wayne, Meek Stephen, Millan Jaime, Cutillas Pedro R, Smith Andrew J H, Ridley Anne J, Ruhrberg Christiana, Gerhardt Holger, Vanhaesebroeck Bart, ;2008;Nature;453;662-6; 18449193

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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