B6.129P2-Pik3ca^tm3Bvan/Orl

Status	Available to order
EMMA ID	EM:11394
International strain name	B6.129P2-Pik3ca^tm3Bvan/Orl
Alternative name	B6.129P2-Pik3catm1Bvan/J
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Pik3ca^tm3Bvan,
Gene/Transgene symbol	Pik3ca

Information from provider

Provider	Bart Vanhaesebroeck
Provider affiliation	UCL Cancer Institute, University College London
Additional owner	the University of Edinburgh
Genetic information	Exons 18 and 19 of the Pik3ca (PIK3CA/p110alpha) gene are flanked by loxP sites; backcrossed to C57BL/6J background.
Phenotypic information	Homozygous: Mice are phenotypically normal. Heterozygous: Mice are phenotypically normal.
Breeding history	Backcrossed to C57BL/6J for more than 10 generations.
References	Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.;Graupera Mariona, Guillermet-Guibert Julie, Foukas Lazaros C, Phng Li-Kun, Cain Robert J, Salpekar Ashreena, Pearce Wayne, Meek Stephen, Millan Jaime, Cutillas Pedro R, Smith Andrew J H, Ridley Anne J, Ruhrberg Christiana, Gerhardt Holger, Vanhaesebroeck Bart, ;2008;Nature;453;662-6; 18449193
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Macrodactyly of toes, unilateral / Orphanet_295243
Adult hepatocellular carcinoma / Orphanet_210159
Hemimegalencephaly / Orphanet_99802
Hemihyperplasia-multiple lipomatosis syndrome / Orphanet_276280
Segmental progressive overgrowth syndrome with fibroadipose hyperplasia / Orphanet_314662
CLOVES syndrome / Orphanet_140944
Megalencephaly-capillary malformation-polymicrogyria syndrome / Orphanet_60040
Macrodactyly of fingers, unilateral / Orphanet_295239
Cowden syndrome / Orphanet_201
Meningioma / Orphanet_2495

Literature references

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.;Graupera Mariona, Guillermet-Guibert Julie, Foukas Lazaros C, Phng Li-Kun, Cain Robert J, Salpekar Ashreena, Pearce Wayne, Meek Stephen, Millan Jaime, Cutillas Pedro R, Smith Andrew J H, Ridley Anne J, Ruhrberg Christiana, Gerhardt Holger, Vanhaesebroeck Bart, ;2008;Nature;453;662-6; 18449193

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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B6.129P2-Pik3catm3Bvan/Orl