B6.129P2-Pik3catm2Bvan/Orl

Status

Available to order

EMMA IDEM:11395
Citation informationRRID:IMSR_EM:11395 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129P2-Pik3catm2Bvan/Orl
Alternative nameB6.129P2-Pik3catm1(lacz)Bvan/J
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolPik3catm2Bvan
Gene/Transgene symbolPik3ca

Information from provider

ProviderBart Vanhaesebroeck
Provider affiliationUCL Cancer Institute, University College London
Additional ownerthe University of Edinburgh
Genetic informationIntroduced by homologous recombination in the Pik3ca locus: C-terminal Myc tag added to the C-terminus of the p110alpha protein + IRES-lacZ-MC1-neo marker/selection cassette, flanked by loxP sites.
Phenotypic informationHomozygous:
Have not been characterised in detail as homo- or heterozygous mice express lacZ under the control of the p110alpha/Pik3ca promoter.

Heterozygous:
Have not been characterised in any detail as homo- or heterozygous mice express lacZ under the control of the p110alpha/Pik3ca promoter.
Breeding historyBackcrossed onto C57BL/6J for more than 10 generations.
References
  • Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.;Foukas Lazaros C, Claret Marc, Pearce Wayne, Okkenhaug Klaus, Meek Stephen, Peskett Emma, Sancho Sara, Smith Andrew J H, Withers Dominic J, Vanhaesebroeck Bart, ;2006;Nature;441;366-70; 16625210
  • Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.;Eickholt Britta J, Ahmed Aminul I, Davies Meirion, Papakonstanti Evangelia A, Pearce Wayne, Starkey Michelle L, Bilancio Antonio, Need Anna C, Smith Andrew J H, Hall Susan M, Hamers Frank P, Giese Karl P, Bradbury Elizabeth J, Vanhaesebroeck Bart, ;2007;PloS one;2;e869; 17846664
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • vasculature congestion / MGI
  • abnormal vascular development / MGI
  • abnormal angiogenesis / MGI
  • decreased cell proliferation / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • polyphagia / MGI
  • internal hemorrhage / MGI
  • abnormal somite development / MGI
  • decreased embryo size / MGI
  • pale yolk sac / MGI
  • embryonic growth arrest / MGI
  • postnatal growth retardation / MGI
  • abnormal lymphatic vessel morphology / MGI
  • hemorrhage / MGI
  • neoplasm / MGI
  • increased circulating insulin level / MGI
  • abnormal retinal vasculature morphology / MGI
  • no phenotypic analysis / MGI
  • abnormal vitelline vasculature morphology / MGI
  • increased pancreatic beta cell number / MGI
  • decreased lean body mass / MGI
  • abnormal endocardium morphology / MGI
  • embryonic growth retardation / MGI
  • abnormal vitelline vascular remodeling / MGI
  • fetal growth retardation / MGI
  • decreased incidence of tumors by chemical induction / MGI
  • abnormal anterior cardinal vein morphology / MGI
  • abnormal dorsal aorta morphology / MGI
  • decreased skeletal muscle mass / MGI
  • abnormal brain vasculature morphology / MGI
  • impaired glucose tolerance / MGI
  • insulin resistance / MGI
  • abnormal cell physiology / MGI
  • increased circulating leptin level / MGI
  • increased fat cell size / MGI
  • abnormal lymphangiogenesis / MGI
  • mortality/aging / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • chylous ascites / MGI
  • abnormal intersomitic vessel morphology / MGI
  • abnormal perineural vascular plexus morphology / MGI

Literature references

  • Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.;Foukas Lazaros C, Claret Marc, Pearce Wayne, Okkenhaug Klaus, Meek Stephen, Peskett Emma, Sancho Sara, Smith Andrew J H, Withers Dominic J, Vanhaesebroeck Bart, ;2006;Nature;441;366-70; 16625210
  • Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.;Eickholt Britta J, Ahmed Aminul I, Davies Meirion, Papakonstanti Evangelia A, Pearce Wayne, Starkey Michelle L, Bilancio Antonio, Need Anna C, Smith Andrew J H, Hall Susan M, Hamers Frank P, Giese Karl P, Bradbury Elizabeth J, Vanhaesebroeck Bart, ;2007;PloS one;2;e869; 17846664

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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