B6.129P2-Pik3catm2Bvan/Orl
| Status | Available to order |
| EMMA ID | EM:11395 |
| International strain name | B6.129P2-Pik3catm2Bvan/Orl |
| Alternative name | B6.129P2-Pik3catm1(lacz)Bvan/J |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Pik3catm2Bvan, |
| Gene/Transgene symbol | Pik3ca |
Information from provider
| Provider | Bart Vanhaesebroeck |
| Provider affiliation | UCL Cancer Institute, University College London |
| Additional owner | the University of Edinburgh |
| Genetic information | Introduced by homologous recombination in the Pik3ca locus: C-terminal Myc tag added to the C-terminus of the p110alpha protein + IRES-lacZ-MC1-neo marker/selection cassette, flanked by loxP sites. |
| Phenotypic information | Homozygous:Have not been characterised in detail as homo- or heterozygous mice express lacZ under the control of the p110alpha/Pik3ca promoter.Heterozygous:Have not been characterised in any detail as homo- or heterozygous mice express lacZ under the control of the p110alpha/Pik3ca promoter. |
| Breeding history | Backcrossed onto C57BL/6J for more than 10 generations. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Macrodactyly of toes, unilateral / Orphanet_295243
- Adult hepatocellular carcinoma / Orphanet_210159
- Hemimegalencephaly / Orphanet_99802
- Hemihyperplasia-multiple lipomatosis syndrome / Orphanet_276280
- Segmental progressive overgrowth syndrome with fibroadipose hyperplasia / Orphanet_314662
- CLOVES syndrome / Orphanet_140944
- Megalencephaly-capillary malformation-polymicrogyria syndrome / Orphanet_60040
- Macrodactyly of fingers, unilateral / Orphanet_295239
- Cowden syndrome / Orphanet_201
- Meningioma / Orphanet_2495
Literature references
- Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.;Foukas Lazaros C, Claret Marc, Pearce Wayne, Okkenhaug Klaus, Meek Stephen, Peskett Emma, Sancho Sara, Smith Andrew J H, Withers Dominic J, Vanhaesebroeck Bart, ;2006;Nature;441;366-70; 16625210
- Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.;Eickholt Britta J, Ahmed Aminul I, Davies Meirion, Papakonstanti Evangelia A, Pearce Wayne, Starkey Michelle L, Bilancio Antonio, Need Anna C, Smith Andrew J H, Hall Susan M, Hamers Frank P, Giese Karl P, Bradbury Elizabeth J, Vanhaesebroeck Bart, ;2007;PloS one;2;e869; 17846664