IMPC phenotypes (allele matching)
C57BL/6NTac-Trp73em1(IMPC)H/H
| Status | Available to order |
| EMMA ID | EM:11422 |
| Citation information | RRID:IMSR_EM:11422 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Trp73em1(IMPC)H/H |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Trp73em1(IMPC)H |
| Gene/Transgene symbol | Trp73 |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6NTac (USA) males, heterozygous C57BL/6NTac (USA) females |
Disease and phenotype information
MGI phenotypes (gene matching)
- absent Cajal-Retzius cell / MGI
- domed cranium / MGI
- gastrointestinal hemorrhage / MGI
- absent enterocytes / MGI
- excessive digestive secretion / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal cortical marginal zone morphology / MGI
- abnormal hippocampus morphology / MGI
- abnormal hippocampus development / MGI
- abnormal dentate gyrus morphology / MGI
- abnormal choroid plexus morphology / MGI
- dilated lateral ventricles / MGI
- abnormal hypothalamus morphology / MGI
- abnormal trigeminal ganglion morphology / MGI
- decreased body size / MGI
- submission towards male mice / MGI
- reduced male mating frequency / MGI
- abnormal embryo development / MGI
- periorbital edema / MGI
- increased susceptibility to otitis media / MGI
- conjunctivitis / MGI
- rhinitis / MGI
- sinus inflammation / MGI
- hydroencephaly / MGI
- non-obstructive hydrocephaly / MGI
- abnormal cerebrospinal fluid production / MGI
- intracranial hemorrhage / MGI
- intraventricular hemorrhage / MGI
- reduced fertility / MGI
- male infertility / MGI
- female infertility / MGI
- abnormal ovulation / MGI
- neoplasm / MGI
- increased cellular sensitivity to gamma-irradiation / MGI
- increased malignant tumor incidence / MGI
- increased tumor incidence / MGI
- increased T cell derived lymphoma incidence / MGI
- increased lung adenocarcinoma incidence / MGI
- increased carcinoma incidence / MGI
- increased lung adenoma incidence / MGI
- premature death / MGI
- neurodegeneration / MGI
- abnormal vomeronasal organ morphology / MGI
- increased susceptibility to bacterial infection / MGI
- chronic inflammation / MGI
- abnormal hippocampal mossy fiber morphology / MGI
- abnormal cell cycle / MGI
- increased neuron apoptosis / MGI
- abnormal forebrain development / MGI
- increased hemangiosarcoma incidence / MGI
- maternal effect / MGI
- abnormal chromosome number / MGI
- polyploidy / MGI
- increased incidence of tumors by chemical induction / MGI
- cachexia / MGI
- abnormal female meiosis / MGI
- decreased oocyte number / MGI
- decreased Cajal-Retzius cell number / MGI
- abnormal dendrite morphology / MGI
- abnormal hippocampus CA3 region morphology / MGI
- anovulation / MGI
- abnormal ovarian follicle number / MGI
- increased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced cell death / MGI
- decreased neuron number / MGI
- distended ileum / MGI
- increased thymocyte apoptosis / MGI
- abnormal meiotic spindle morphology / MGI
- abnormal hippocampus neuron morphology / MGI
- postnatal lethality, incomplete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- increased lymphoma incidence / MGI