| Status | Available to order |
| EMMA ID | EM:11456 |
| International strain name | C57BL/6J-Ythdc2em2Embrp/Cnrm |
| Alternative name | Ythdc2 KO (C57BL6J) |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Ythdc2em2Embrp, |
| Gene/Transgene symbol | Ythdc2 |
| Provider | Ramesh PILLAI |
| Provider affiliation | Department of Molecular Biology, University of Geneva |
| Genetic information | Deletion of the exon7 of the Ythdc2 gene to generate a knock-out mouse. Exon7 encodes for the catalytic residues required for ATPase activity of the protein. |
| Phenotypic information | Homozygous:Homozygous males and females are infertile.Heterozygous:Heterozygous males and females display no detectable phenotypes. They are viable and fertile. |
| Breeding history | Founders generated using CRISPR-Cas9 injection into 1-cell embryos of the C57BL/6J genetic background were crossed with wild-type C57BL/6J partners to produce heterozygous animals. These heterozygous animals were then intercrossed over 5 generations to generate the current animals being sent to EMMA. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
