MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
B6.129P2-Pik3cdtm1Bvan/IcsOrl
| Status | Available to order |
| EMMA ID | EM:11501 |
| International strain name | B6.129P2-Pik3cdtm1Bvan/IcsOrl |
| Alternative name | p110delta PI3K WT-Myc-IRES-LacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Pik3cdtm1Bvan, |
| Gene/Transgene symbol | Pik3cd |
Information from provider
| Provider | Bart Vanhaesebroeck |
| Provider affiliation | UCL Cancer Institute, University College London |
| Additional owner | Co-developed by the Ludwig Institute for Cancer Research (LICR) and the University of Edinburgh, UK. The materials are available to academic researchers. Commercial entity need to obtain a licensing agreement. |
| Genetic information | Introduced by homologous recombination in the Pik3cd locus: Myc tag added to the C-terminus of the p110delta protein plus IRES-lacZ-MC1-neo marker/selection cassette, flanked by loxP sites |
| Phenotypic information | Homozygous:Not characterised as homozygous miceHeterozygous:Mice are expected to have an inactivated p110delta due to the presence of C-terminal Myc-tag and express lacZ reporter where p110delta is expressed |
| Breeding history | Backcrossed onto C57BL/6J for more than 10 generations |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Activated PI3K-delta syndrome / Orphanet_397596
- Combined immunodeficiency with faciooculoskeletal anomalies / Orphanet_221139
Literature references
- Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice.;Okkenhaug Klaus, Bilancio Antonio, Farjot Géraldine, Priddle Helen, Sancho Sara, Peskett Emma, Pearce Wayne, Meek Stephen E, Salpekar Ashreena, Waterfield Michael D, Smith Andrew J H, Vanhaesebroeck Bart, ;2002;Science (New York, N.Y.);297;1031-4; 12130661
- Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.;Eickholt Britta J, Ahmed Aminul I, Davies Meirion, Papakonstanti Evangelia A, Pearce Wayne, Starkey Michelle L, Bilancio Antonio, Need Anna C, Smith Andrew J H, Hall Susan M, Hamers Frank P, Giese Karl P, Bradbury Elizabeth J, Vanhaesebroeck Bart, ;2007;PloS one;2;e869; 17846664