MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
B6.129P2-Pik3cdtm1Bvan/IcsOrl
| Status | Available to order |
| EMMA ID | EM:11501 |
| Citation information | RRID:IMSR_EM:11501 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Pik3cdtm1Bvan/IcsOrl |
| Alternative name | p110delta PI3K WT-Myc-IRES-LacZ |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Pik3cdtm1Bvan |
| Gene/Transgene symbol | Pik3cd |
Information from provider
| Provider | Bart Vanhaesebroeck |
| Provider affiliation | UCL Cancer Institute, University College London |
| Additional owner | Co-developed by the Ludwig Institute for Cancer Research (LICR) and the University of Edinburgh, UK. The materials are available to academic researchers. Commercial entity need to obtain a licensing agreement. |
| Genetic information | Introduced by homologous recombination in the Pik3cd locus: Myc tag added to the C-terminus of the p110delta protein plus IRES-lacZ-MC1-neo marker/selection cassette, flanked by loxP sites |
| Phenotypic information | Homozygous:Not characterised as homozygous miceHeterozygous:Mice are expected to have an inactivated p110delta due to the presence of C-terminal Myc-tag and express lacZ reporter where p110delta is expressed |
| Breeding history | Backcrossed onto C57BL/6J for more than 10 generations |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Activated PI3K-delta syndrome / Orphanet_397596
- Combined immunodeficiency with faciooculoskeletal anomalies / Orphanet_221139
MGI phenotypes (gene matching)
- increased leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- abnormal intestinal epithelium morphology / MGI
- crypts of Lieberkuhn abscesses / MGI
- abnormal intestinal mucosa morphology / MGI
- small spleen / MGI
- spleen hypoplasia / MGI
- impaired hematopoiesis / MGI
- abnormal humoral immune response / MGI
- decreased IgG level / MGI
- decreased IgM level / MGI
- decreased IgA level / MGI
- intestinal inflammation / MGI
- decreased inflammatory response / MGI
- abnormal B cell differentiation / MGI
- small lymph nodes / MGI
- abnormal Peyer's patch germinal center morphology / MGI
- increased susceptibility to viral infection / MGI
- abnormal B cell physiology / MGI
- decreased immunoglobulin level / MGI
- increased IgE level / MGI
- no phenotypic analysis / MGI
- decreased susceptibility to induced arthritis / MGI
- decreased B-1 B cell number / MGI
- increased lymphocyte cell number / MGI
- decreased B cell number / MGI
- decreased B cell proliferation / MGI
- cardiovascular system phenotype / MGI
- immune system phenotype / MGI
- decreased B-1a cell number / MGI
- decreased marginal zone B cell number / MGI
- absent B-1 B cells / MGI
- decreased B-2 B cell number / MGI
- decreased mature B cell number / MGI
- absent spleen germinal center / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- increased circulating interferon-alpha level / MGI
- abnormal platelet aggregation / MGI
- decreased response to antigen / MGI
- increased response to antigen / MGI
Literature references
- Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice.;Okkenhaug Klaus, Bilancio Antonio, Farjot Géraldine, Priddle Helen, Sancho Sara, Peskett Emma, Pearce Wayne, Meek Stephen E, Salpekar Ashreena, Waterfield Michael D, Smith Andrew J H, Vanhaesebroeck Bart, ;2002;Science (New York, N.Y.);297;1031-4; 12130661
- Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.;Eickholt Britta J, Ahmed Aminul I, Davies Meirion, Papakonstanti Evangelia A, Pearce Wayne, Starkey Michelle L, Bilancio Antonio, Need Anna C, Smith Andrew J H, Hall Susan M, Hamers Frank P, Giese Karl P, Bradbury Elizabeth J, Vanhaesebroeck Bart, ;2007;PloS one;2;e869; 17846664