B6.Cg-Pik3cdtm1(S1039A)Bvan/Orl

Status

Available to order

EMMA IDEM:11502
Citation informationRRID:IMSR_EM:11502 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.Cg-Pik3cdtm1(S1039A)Bvan/Orl
Alternative namep110delta PI3K S1039A
Strain typeTargeted Mutant Strains : Point mutation
Allele/Transgene symbolPik3cdtm1(S1039A)Bvan
Gene/Transgene symbolPik3cd

Information from provider

ProviderBart Vanhaesebroeck
Provider affiliationUCL Cancer Institute, University College London
Additional ownerDeveloped by the Ludwig Institute for Cancer Research (LICR). The materials are available to academic researchers. Commercial entity need to obtain a licensing agreement.
Genetic informationKnock-in mice in which the endogenous PIK3CD/p110delta PI3K gene is mutated so that it now encodes a p110delta protein with S1039 mutated to alanine.
Phenotypic informationHomozygous:
viable - no phenotypes detected

Heterozygous:
viable - no phenotypes detected
Breeding historyBackcrossed onto C57BL/6J for more than 10 generations.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • increased leukocyte cell number / MGI
  • increased neutrophil cell number / MGI
  • abnormal intestinal epithelium morphology / MGI
  • crypts of Lieberkuhn abscesses / MGI
  • abnormal intestinal mucosa morphology / MGI
  • small spleen / MGI
  • spleen hypoplasia / MGI
  • impaired hematopoiesis / MGI
  • abnormal humoral immune response / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • decreased IgA level / MGI
  • intestinal inflammation / MGI
  • decreased inflammatory response / MGI
  • abnormal B cell differentiation / MGI
  • small lymph nodes / MGI
  • abnormal Peyer's patch germinal center morphology / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal B cell physiology / MGI
  • decreased immunoglobulin level / MGI
  • increased IgE level / MGI
  • no phenotypic analysis / MGI
  • decreased susceptibility to induced arthritis / MGI
  • decreased B-1 B cell number / MGI
  • increased lymphocyte cell number / MGI
  • decreased B cell number / MGI
  • decreased B cell proliferation / MGI
  • cardiovascular system phenotype / MGI
  • immune system phenotype / MGI
  • decreased B-1a cell number / MGI
  • decreased marginal zone B cell number / MGI
  • absent B-1 B cells / MGI
  • decreased B-2 B cell number / MGI
  • decreased mature B cell number / MGI
  • absent spleen germinal center / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • increased circulating interferon-alpha level / MGI
  • abnormal platelet aggregation / MGI
  • decreased response to antigen / MGI
  • increased response to antigen / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).