B6.Cg-Pik3cdtm1(S1039A)Bvan/Orl
| Status | Available to order |
| EMMA ID | EM:11502 |
| International strain name | B6.Cg-Pik3cdtm1(S1039A)Bvan/Orl |
| Alternative name | p110delta PI3K S1039A |
| Strain type | Targeted Mutant Strains : Point mutation |
| Allele/Transgene symbol | Pik3cdtm1(S1039A)Bvan |
| Gene/Transgene symbol | Pik3cd |
Information from provider
| Provider | Bart Vanhaesebroeck |
| Provider affiliation | UCL Cancer Institute, University College London |
| Additional owner | Developed by the Ludwig Institute for Cancer Research (LICR). The materials are available to academic researchers. Commercial entity need to obtain a licensing agreement. |
| Genetic information | Knock-in mice in which the endogenous PIK3CD/p110delta PI3K gene is mutated so that it now encodes a p110delta protein with S1039 mutated to alanine. |
| Phenotypic information | Homozygous:viable - no phenotypes detectedHeterozygous:viable - no phenotypes detected |
| Breeding history | Backcrossed onto C57BL/6J for more than 10 generations. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Activated PI3K-delta syndrome / Orphanet_397596
- Combined immunodeficiency with faciooculoskeletal anomalies / Orphanet_221139