B6N.Cg-Jak1tm1c(EUCOMM)Hmgu/Biat
Status | Available to order |
EMMA ID | EM:11548 |
International strain name | B6N.Cg-Jak1tm1c(EUCOMM)Hmgu/Biat |
Alternative name | C57BL/6N-A |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Jak1tm1c(EUCOMM)Hmgu, |
Gene/Transgene symbol | Jak1 |
Information from provider
Provider | Alexander Dohnal |
Provider affiliation | Tumor Immunology, St. Anna Kinderkrebsforschung |
Genetic information | This line originates from EUCOMM ES clone HEPD0646_3_H04, after breeding the resulting tm1a strain (EM:06879, C57BL/6N-Atm1Brd Jak1tm1a(EUCOMM)Hmgu/Biat) with a flp recombinase deleter line to convert the original targeted tm1a (knock-out first) allele into a conditional tm1c allele. |
Phenotypic information | Homozygous:noneHeterozygous:none |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive mendelian susceptibility to mycobacterial diseases due to partial JAK1 deficiency / Orphanet_574957
Literature references
- Loss of JAK1 Drives Innate Immune Deficiency.;Witalisz-Siepracka Agnieszka, Klein Klara, Prinz Daniela, Leidenfrost Nicoletta, Schabbauer Gernot, Dohnal Alexander, Sexl Veronika, ;2018;Frontiers in immunology;9;3108; 30671064
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