IMPC phenotypes (allele matching)
C57BL/6NTac-Sncaem1(IMPC)H/H
| Status | Available to order |
| EMMA ID | EM:11550 |
| Citation information | RRID:IMSR_EM:11550 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Sncaem1(IMPC)H/H |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Sncaem1(IMPC)H |
| Gene/Transgene symbol | Snca |
Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | wild-type C57BL/6NTac (USA) males, heterozygous C57BL/6N females |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hereditary late-onset Parkinson disease / Orphanet_411602
- Parkinsonian-pyramidal syndrome / Orphanet_171695
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- impaired coordination / MGI
- reduced long term potentiation / MGI
- no abnormal phenotype detected / MGI
- decreased susceptibility to bacterial infection / MGI
- catalepsy / MGI
- no phenotypic analysis / MGI
- abnormal dopaminergic neuron morphology / MGI
- abnormal locomotor activation / MGI
- nervous system phenotype / MGI
- abnormal synaptic transmission / MGI
- abnormal miniature excitatory postsynaptic currents / MGI
- cellular phenotype / MGI
- behavior/neurological phenotype / MGI
- decreased dopamine level / MGI
- increased physiological sensitivity to xenobiotic / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- long stride length / MGI
- mortality/aging / MGI
- abnormal respiratory electron transport chain / MGI
- decreased dopaminergic neuron number / MGI
- decreased susceptibility to dopaminergic neuron neurotoxicity / MGI