C57BL/6N-Atm1Brd Gas2l2tm1a(KOMP)Wtsi/WtsiOulu

Status

Available to order

EMMA IDEM:11597
International strain nameC57BL/6N-Atm1Brd Gas2l2tm1a(KOMP)Wtsi/WtsiOulu
Alternative nameEPD0626_4_G11
Strain typeTargeted Mutant Strains
Allele/Transgene symbolGas2l2tm1a(KOMP)Wtsi,
Gene/Transgene symbolGas2l2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0626_4_G11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • abnormal bone structure / IMPC
  • increased lean body mass / IMPC
  • absent pinna reflex / IMPC
  • decreased total body fat amount / IMPC
MGI phenotypes (allele matching)
  • abnormal basisphenoid bone morphology / MGI
  • abnormal vertebral body morphology / MGI
  • abnormal snout morphology / MGI
  • enlarged liver sinusoidal spaces / MGI
  • absent salivary gland / MGI
  • abnormal forebrain morphology / MGI
  • abnormal midbrain morphology / MGI
  • incomplete rostral neuropore closure / MGI
  • fused dorsal root ganglion / MGI
  • anophthalmia / MGI
  • aphakia / MGI
  • biliary cyst / MGI
  • abnormal auditory tube / MGI
  • dilated ureter / MGI
  • abnormal eye muscle morphology / MGI
  • abnormal optic stalk morphology / MGI
  • absent vertebral arch / MGI
  • fusion of vertebral arches / MGI
  • absent stapedial artery / MGI
  • abnormal Meckel's cartilage morphology / MGI
  • oral atresia / MGI
  • absent tongue / MGI
  • perimembraneous ventricular septal defect / MGI
  • absent optic cup / MGI
  • absent segment of anterior cerebral artery / MGI
  • abnormal Mullerian duct topology / MGI
  • trigeminal neuroma / MGI
  • abnormal ductus venosus valve morphology / MGI
  • abnormal thymus topology / MGI
  • abnormal left vena cava superior connection / MGI
  • abnormal external carotid artery origin / MGI
  • abnormal vertebral artery topology / MGI
  • embryo tumor / MGI

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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