B6.129P2-Pik3cbtm1(lacz-D931A)Bvan/Cnbc
| Status | Available to order |
| EMMA ID | EM:11632 |
| International strain name | B6.129P2-Pik3cbtm1(lacz-D931A)Bvan/Cnbc |
| Alternative name | p110beta PI3K-D931A-LacZ |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | p110βlz |
| Gene/Transgene symbol | Pik3cb |
Information from provider
| Provider | Bart Vanhaesebroeck |
| Provider affiliation | UCL Cancer Institute, University College London |
| Additional owner | the University of Edinburgh |
| Genetic information | An IRES-lacZ-MC1-neo marker/selection cassette, flanked by loxP sites, was inserted after the STOP codon in the last exon (24) of Pik3cb/p110beta PI3K. Knock-in with lacZ cassette. |
| Phenotypic information | Homozygous:Have not been characterised in detail as homo- or heterozygous express lacZ under the control of the Pik3cb/p110beta PI3K promotor.Heterozygous:Mice show reduced phenotypes of homozygous. LacZ expression is reduced compared with homozygotes. |
| Breeding history | Backcrossed onto C57BL/6J for more than 10 generations. |
| References | None available |
| Homozygous fertile | females only |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6OlaHsd |