IMPC phenotypes (gene matching)
129-Pik3cbtm1.1Bvan/Cnbc
| Status | Available to order |
| EMMA ID | EM:11633 |
| Citation information | RRID:IMSR_EM:11633 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129-Pik3cbtm1.1Bvan/Cnbc |
| Alternative name | p110beta PI3K-DEL21/22(129) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Pik3cbtm1.1Bvan |
| Gene/Transgene symbol | Pik3cb |
Information from provider
| Provider | Bart Vanhaesebroeck |
| Provider affiliation | UCL Cancer Institute, University College London |
| Additional owner | the University of Edinburgh |
| Genetic information | Mice in which exons 21 and 22 from Pik3cb/p110beta are constitutively deleted by crossing to a cre-deleter strain - backcrossed onto 129 background. |
| Phenotypic information | Homozygous:Homozygous Pik3cb/p110beta D21-22/D21-22 mice can be obtained but at reduced frequency, it depends on the genetic background.Heterozygous:Mice show reduced phenotypes of homozygous. |
| Breeding history | Backcrossed onto 129Sv for more than 10 generations. |
| References |
|
| Homozygous fertile | females only |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous 129S2/SvPasCrl males |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased body weight / MGI
- weight loss / MGI
- decreased embryo size / MGI
- postnatal growth retardation / MGI
- decreased circulating triglyceride level / MGI
- increased insulin secretion / MGI
- abnormal gluconeogenesis / MGI
- decreased lumbar vertebrae number / MGI
- decreased circulating cholesterol level / MGI
- insulin resistance / MGI
- decreased heart rate / MGI
- decreased glycogen level / MGI
- abnormal platelet physiology / MGI
- pancreatic islet hyperplasia / MGI
- decreased circulating creatinine level / MGI
- increased circulating glucose level / MGI
- increased mean corpuscular hemoglobin / MGI
- increased hemoglobin content / MGI
- increased lung weight / MGI
- pulmonary fibrosis / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- decreased platelet aggregation / MGI
- decreased birth body size / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- embryonic lethality between somite formation and embryo turning, complete penetrance / MGI
- preweaning lethality, complete penetrance / MGI
- embryonic lethality, incomplete penetrance / MGI
- embryonic lethality before implantation, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- decreased fibroblast proliferation / MGI
Literature references
- The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.;Guillermet-Guibert Julie, Bjorklof Katja, Salpekar Ashreena, Gonella Cristiano, Ramadani Faruk, Bilancio Antonio, Meek Stephen, Smith Andrew J H, Okkenhaug Klaus, Vanhaesebroeck Bart, ;2008;Proceedings of the National Academy of Sciences of the United States of America;105;8292-7; 18544649