IMPC phenotypes (gene matching)
- preweaning lethality, incomplete penetrance / IMPC
B6NTac(Cg)-Raph1tm1.1Makr/H
| Status | Available to order |
| EMMA ID | EM:11784 |
| Citation information | RRID:IMSR_EM:11784 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6NTac(Cg)-Raph1tm1.1Makr/H |
| Alternative name | Raph1tm1.1Makr |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Raph1tm1.1Makr |
| Gene/Transgene symbol | Raph1 |
Information from provider
| Provider | Matthias Krause |
| Provider affiliation | Randall Centre for Cell & Molecular Biophysics, King |
| Genetic information | An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exon 4 floxed. |
| Phenotypic information | Homozygous:No phenotype in this conditional strain but phenotypes when crossed to cre-deleter or nestin-cre driver strains; see http://www.informatics.jax.org/image/phenoSummary/allele/MGI:5575553 and https://www.ncbi.nlm.nih.gov/pubmed/28710397?dopt=Abstract.Heterozygous:No phenotype in this conditional strain. |
| Breeding history | Maintained on same genetic background |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal rectum morphology / MGI
- rectal prolapse / MGI
- abnormal colon morphology / MGI
- increased inflammatory response / MGI
- increased carcinoma incidence / MGI
- increased susceptibility to bacterial infection / MGI
- no phenotypic analysis / MGI
- intestinal edema / MGI
- large intestinal inflammation / MGI
- abnormal cytokine level / MGI
- increased myeloid cell number / MGI
Literature references
- Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo.;Law Ah-Lai, Vehlow Anne, Kotini Maria, Dodgson Lauren, Soong Daniel, Theveneau Eric, Bodo Cristian, Taylor Eleanor, Navarro Christel, Perera Upamali, Michael Magdalene, Dunn Graham A, Bennett Daimark, Mayor Roberto, Krause Matthias, ;2013;The Journal of cell biology;203;673-89; 24247431
- Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice.;Bodo Cristian, Fernandes Cathy, Krause Matthias, ;2017;Scientific reports;7;5365; 28710397