Sprague Dawley rat Del(Dyrk1a)/YahIcsOrl

Status	Available to order
EMMA ID	EM:11792
Citation information	EM:11792
International strain name	Sprague Dawley rat Del(Dyrk1a)/YahIcsOrl
Alternative name	Sprague Dawley rat Del(Dyrk1a)
Strain type	Endonuclease-mediated
Allele/Transgene symbol	rat Del^Dyrk1a
Gene/Transgene symbol	rat Dyrk1a

Information from provider

Provider	Yann HERAULT
Provider affiliation	Translational Medicine and Neurogenetics, I.G.B.M.C.
Genetic information	Sprague Dawley rat. Deletion of the entire coding sequence of Dyrk1a gene (121kb) using CRISPR/Cas9 engineering. For the techniques used on all our rat models see PMID: 28266534.
Phenotypic information	Homozygous: Rat homozygous are not viable Heterozygous: Growth delay, craniofacial dysmorphies, susceptibility to epileptic seizures.
Breeding history	1 backcross on Sprague Dawley background
References	Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE.;Birling Marie-Christine, Schaeffer Laurence, André Philippe, Lindner Loic, Maréchal Damien, Ayadi Abdel, Sorg Tania, Pavlovic Guillaume, Hérault Yann, ;2017;Scientific reports;7;43331; 28266534
Homozygous fertile	no
Homozygous viable	no
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France
Animals used for archiving	heterozygous rat Sprague-Dawley males
Stage of embryos	2-cell

Literature references

Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE.;Birling Marie-Christine, Schaeffer Laurence, André Philippe, Lindner Loic, Maréchal Damien, Ayadi Abdel, Sorg Tania, Pavlovic Guillaume, Hérault Yann, ;2017;Scientific reports;7;43331; 28266534

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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