C57BL/6N-Grpel1^{tm1a(EUCOMM)Wtsi}/Oulu

Status	Available to order
EMMA ID	EM:11804
Citation information	RRID:IMSR_EM:11804 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-Grpel1^{tm1a(EUCOMM)Wtsi}/Oulu
Alternative name	Grpel1tm1a(EUCOMM)Wtsi; GrpE-like 1, mitochondrial; targeted mutation 1a
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Grpel1^{tm1a(EUCOMM)Wtsi}
Gene/Transgene symbol	Grpel1

Information from provider

Provider	Henna Tyynismaa
Provider affiliation	Research Program for Molecular Neurology, University of Helsinki
Genetic information	Mutation details: The L1L2_Bact_P cassette was inserted at position 36468949 of chromosome 5 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 36469864. The critical exon(s) is/are thus flanked by loxP sites. ES cell clone EPD0158_3_F01.
Phenotypic information	Homozygous: Not analyzed Heterozygous: No obvious phenotype
References	Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle.;Neupane Nirajan, Rajendran Jayasimman, Kvist Jouni, Harjuhaahto Sandra, Hu Bowen, Kinnunen Veijo, Yang Yang, Nieminen Anni I, Tyynismaa Henna, ;2022;Communications biology;5;1060; 36198903
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	not known
Immunocompromised	no

Information from EMMA

Archiving centre	University of Oulu, Oulu, Finland
Animals used for archiving	heterozygous C57BL/6NCrl males, wild-type females
Stage of embryos	2-cell

Literature references

Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle.;Neupane Nirajan, Rajendran Jayasimman, Kvist Jouni, Harjuhaahto Sandra, Hu Bowen, Kinnunen Veijo, Yang Yang, Nieminen Anni I, Tyynismaa Henna, ;2022;Communications biology;5;1060; 36198903

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6N-Grpel1tm1a(EUCOMM)Wtsi/Oulu