rat SD-Del(11App)1Yah/YahIcsOrl
| Status | Available to order |
| EMMA ID | EM:11820 |
| Citation information | EM:11820 |
| International strain name | rat SD-Del(11App)1Yah/YahIcsOrl |
| Alternative name | Sprague Dawley rat Rno11_Del(App) |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | rat Del(11App)1Yah |
| Gene/Transgene symbol | rat App |
Information from provider
| Provider | Yann HERAULT |
| Provider affiliation | I.G.B.M.C. |
| Genetic information | Deletion of 43 bp at the end of exon 16 of the rat App gene, by CRISPR/Cas9 system. For the techniques used on all our rat models see PMID: 28266534. |
| Phenotypic information | Homozygous:Growth delay but normal lifespan.Heterozygous:No difference compared to control. |
| Breeding history | 1 backcross on Sprague-Dawley genetic background. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | wild-type rat Sprague-Dawley females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- ABeta amyloidosis, Italian type / Orphanet_324713
- ABetaL34V amyloidosis / Orphanet_324703
- ABeta amyloidosis, Arctic type / Orphanet_324723
- ABetaA21G amyloidosis / Orphanet_324718
- ABeta amyloidosis, Dutch type / Orphanet_100006
- ABeta amyloidosis, Iowa type / Orphanet_324708
- Early-onset autosomal dominant Alzheimer disease / Orphanet_1020
Literature references
- Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE.;Birling Marie-Christine, Schaeffer Laurence, André Philippe, Lindner Loic, Maréchal Damien, Ayadi Abdel, Sorg Tania, Pavlovic Guillaume, Hérault Yann, ;2017;Scientific reports;7;43331; 28266534