rat SD-Del(1Sult1a1-Spn)Yah/YahIcsOrl

Status	Available to order
EMMA ID	EM:11821
Citation information	EM:11821
International strain name	rat SD-Del(1Sult1a1-Spn)Yah/YahIcsOrl
Alternative name	Sprague Dawley rat Rno1_Del(Sult1a1-Spn)
Strain type	Endonuclease-mediated
Allele/Transgene symbol	rat Del(1Sult1a1-Spn)1Yah
Gene/Transgene symbol	rat Del(1Sult1a1-Spn)1Yah

Information from provider

Provider	Yann HERAULT
Provider affiliation	Translational Medicine and Neurogenetics, I.G.B.M.C.
Genetic information	Sprague-Dawley rat strain. Deletion of the genetic interval Sult1a1-Spn. We targeted an extended sequence of the whole locus from one allele and the CRISPR/Cas9 system allowed us to remove the region encompassing 28 genes, orthologous to human.
Phenotypic information	Homozygous: Homozygous rats were not generated. Heterozygous: Growth delay and hyperactive behaviour.
Breeding history	1 backcross on Sprague-Dawley genetic background.
References	Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development.;Qiu Yuqi, Arbogast Thomas, Lorenzo Sandra Martin, Li Hongying, Tang Shih C, Richardson Ellen, Hong Oanh, Cho Shawn, Shanta Omar, Pang Timothy, Corsello Christina, Deutsch Curtis K, Chevalier Claire, Davis Erica E, Iakoucheva Lilia M, Herault Yann, Katsanis Nicholas, Messer Karen, Sebat Jonathan, ;2019;Cell reports;28;3320-3328.e4; 31553903
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Animals used for archiving	heterozygous rat Sprague-Dawley males, wild-type rat Sprague-Dawley females
Stage of embryos	2-cell

Literature references

Oligogenic Effects of 16p11.2 Copy-Number Variation on Craniofacial Development.;Qiu Yuqi, Arbogast Thomas, Lorenzo Sandra Martin, Li Hongying, Tang Shih C, Richardson Ellen, Hong Oanh, Cho Shawn, Shanta Omar, Pang Timothy, Corsello Christina, Deutsch Curtis K, Chevalier Claire, Davis Erica E, Iakoucheva Lilia M, Herault Yann, Katsanis Nicholas, Messer Karen, Sebat Jonathan, ;2019;Cell reports;28;3320-3328.e4; 31553903

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

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Practical information

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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