STOCK Selenontm1.2Mred Gulotm1Mae/Cnrm

Status

Available to order

EMMA IDEM:11938
International strain nameSTOCK Selenontm1.2Mred Gulotm1Mae/Cnrm
Alternative nameSEPN1, GULO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolGulotm1Mae,
Gene/Transgene symbolGulo

Information from provider

ProviderEster Zito
Provider affiliationIstituto di Ricerche Farmacologiche Mario Negri
Genetic informationThe strain that we want to freeze is a compound mutant for Sepn1 mutation and gulonolactone oxidase mutation.
Phenotypic informationHomozygous:
The compound Sepn1, Gulo KO mice show a myopathic phenotype at low concentration of ascorbic acid.

Heterozygous:
The heterozygous mutant does not show an over muscle phenotype.
References
  • Endoplasmic Reticulum Oxidative Stress Triggers Tgf-Beta-Dependent Muscle Dysfunction by Accelerating Ascorbic Acid Turnover.;Pozzer Diego, Favellato Mariagrazia, Bolis Marco, Invernizzi Roberto William, Solagna Francesca, Blaauw Bert, Zito Ester, ;2017;Scientific reports;7;40993; 28106121
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal muscle regeneration / MGI
  • abnormal muscle physiology / MGI
  • decreased satellite cell number / MGI
  • skeletal muscle atrophy / MGI
  • kyphosis / MGI
  • abnormal skeletal muscle morphology / MGI
  • decreased skeletal muscle mass / MGI
  • decreased skeletal muscle fiber size / MGI
  • decreased skeletal muscle fiber diameter / MGI
  • centrally nucleated skeletal muscle fibers / MGI
  • abnormal skeletal muscle fiber type ratio / MGI
  • decreased gastrocnemius weight / MGI
  • decreased extensor digitorum longus weight / MGI
  • decreased soleus weight / MGI
  • decreased tibialis anterior weight / MGI
  • decreased susceptibility to weight gain / MGI
  • decreased quadriceps weight / MGI

Literature references

  • Endoplasmic Reticulum Oxidative Stress Triggers Tgf-Beta-Dependent Muscle Dysfunction by Accelerating Ascorbic Acid Turnover.;Pozzer Diego, Favellato Mariagrazia, Bolis Marco, Invernizzi Roberto William, Solagna Francesca, Blaauw Bert, Zito Ester, ;2017;Scientific reports;7;40993; 28106121

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).