B6(Cg)-Tg(Th-rtTA)4Ekra/EkraH
| Status | Available to order |
| EMMA ID | EM:11951 |
| Citation information | RRID:IMSR_EM:11951 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6(Cg)-Tg(Th-rtTA)4Ekra/EkraH |
| Alternative name | C57BL/6J-Tg(TH-rtTA3G)4EKra |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Unknown at present |
| Gene/Transgene symbol | mTH-rtTA3G |
Information from provider
| Provider | Edgar Kramer |
| Provider affiliation | Biomedical Research, Institute of Translational and Stratified Medicine, Peninsula Schools of Medicine and Dentistry, University of Plymouth |
| Genetic information | rtTA3G under the control of the mouse Th promoter (8.9kbp). |
| Phenotypic information | Homozygous:Not generated.Heterozygous:mTH-rtTA ON#3205 can be used to induce rtTA expression in catecholaminergic neurons expressing tyrosine hydroxylase; rtTA can induce gene expression in the presence of tetracycline/doxycycline (Tillack et al., 2015). No obvious phenotype has been observed in the heterozygous mice. |
| Breeding history | Intercrosses with C57BL/6 x BALB/c F2-Tg(tetO-cre)LC1Bjd mouse line. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- An Efficient and Versatile System for Visualization and Genetic Modification of Dopaminergic Neurons in Transgenic Mice.;Tillack Karsten, Aboutalebi Helia, Kramer Edgar R, ;2015;PloS one;10;e0136203; 26291828