FVB-Il31raem1Phep/Cnrm
| Status | Available to order |
| EMMA ID | EM:11960 |
| International strain name | FVB-Il31raem1Phep/Cnrm |
| Alternative name | Il31ra 8bp deletion KO |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Il31raem1Phep, |
| Gene/Transgene symbol | Il31ra |
Information from provider
| Provider | Paul Heppenstall |
| Provider affiliation | European Molecular Biology Laboratory |
| Genetic information | This mouse line was generated by CRISPR/Cas9-mediated genome editing, which knocked out the Il31ra gene by a 8 bp deletion into the exon 14 of the Il31ra locus. |
| Phenotypic information | Homozygous:Homozygous mice show a normal phenotype, are healthy and fertile.Heterozygous:Heterozygous mice show a normal phenotype, are healthy and fertile. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial primary localized cutaneous amyloidosis / Orphanet_353220
Literature references
- Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice.;Nocchi Linda, Roy Nainika, D'Attilia Mariangela, Dhandapani Rahul, Maffei Mariano, Traista Andrei, Castaldi Laura, Perlas Emerald, Chadick Cora Hallie, Heppenstall Paul A, ;2019;Nature biomedical engineering;3;114-125; 30944432
- Molecule guided laser ablation as a novel therapeutic strategy to control itch;Nocchi L, D’Attilia M, Roy N, Dhandapani R, Traista A, Maffei M, Castaldi L, Perlas E, Heppenstall PA;2018;Biorxiv unrefereed preprint full text;;;