C57BL/6N-Atg4btm1a(EUCOMM)Hmgu/H

Status

Available to order

EMMA IDEM:11966
Citation informationRRID:IMSR_EM:11966 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Atg4btm1a(EUCOMM)Hmgu/H
Alternative nameHEPD0752_1_B03
Strain typeTargeted Mutant Strains
Allele/Transgene symbolAtg4btm1a(EUCOMM)Hmgu
Gene/Transgene symbolAtg4b
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0752_1_B03. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal retina morphology / IMPC
  • decreased lean body mass / IMPC
  • cataract / IMPC
  • increased circulating alanine transaminase level / IMPC
  • decreased circulating total protein level / IMPC
  • abnormal auditory brainstem response / IMPC
  • decreased circulating cholesterol level / IMPC
  • limb grasping / IMPC
  • decreased prepulse inhibition / IMPC
  • decreased blood urea nitrogen level / IMPC
  • increased basophil cell number / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • abnormal tooth morphology / IMPC
  • increased fasting circulating glucose level / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • short tibia / IMPC
MGI phenotypes (gene matching)
  • circling / MGI
  • impaired coordination / MGI
  • impaired swimming / MGI
  • abnormal lipid homeostasis / MGI
  • abnormal motor learning / MGI
  • abnormal otolith morphology / MGI
  • absent otoliths / MGI
  • enlarged otoliths / MGI
  • nervous system phenotype / MGI
  • abnormal vestibular saccular macula morphology / MGI
  • head tilt / MGI
  • abnormal utricle morphology / MGI
  • abnormal autophagy / MGI
  • abnormal cerebellum deep nucleus morphology / MGI
  • preweaning lethality, incomplete penetrance / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

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