- increased leukocyte cell number / IMPC
- abnormal skin condition / IMPC
- abnormal cornea morphology / IMPC
- increased circulating free fatty acid level / IMPC
- increased circulating alkaline phosphatase level / IMPC
- decreased lean body mass / IMPC
- increased T cell number / IMPC
- decreased NK cell number / IMPC
- increased CD4-positive, alpha beta T cell number / IMPC
- decreased circulating amylase level / IMPC
- decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
- decreased effector memory CD4-positive, alpha-beta T cell number / IMPC
B6Brd;B6N-Tyrc-Brd Nfkb1tm1a(KOMP)Wtsi/Wtsi
Status | Available to order |
EMMA ID | EM:12090 |
International strain name | B6Brd;B6N-Tyrc-Brd Nfkb1tm1a(KOMP)Wtsi/Wtsi |
Alternative name | EPD0033_4_D01 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Nfkb1tm1a(KOMP)Wtsi, |
Gene/Transgene symbol | Nfkb1 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from KOMP ES clone EPD0033_4_D01. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Wellcome Trust Sanger Institute, Hinxton, United Kingdom |
Animals used for archiving | homozygous C57BL/6Dnk;C57BL/6Brd-Tyr |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Common variable immunodeficiency / Orphanet_1572
IMPC phenotypes (allele matching)
MGI phenotypes (allele matching)
- increased leukocyte cell number / MGI
- lymphoid hyperplasia / MGI
- decreased IgA level / MGI
- increased susceptibility to bacterial infection / MGI
- increased circulating alkaline phosphatase level / MGI
- decreased regulatory T cell number / MGI
- decreased NK cell number / MGI
- decreased IgG1 level / MGI
- decreased respiratory quotient / MGI
- increased circulating free fatty acid level / MGI
- decreased lean body mass / MGI
- decreased mean corpuscular hemoglobin concentration / MGI
- decreased circulating amylase level / MGI
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