B6Brd;B6N-Tyrc-Brd Nfkb1tm1a(KOMP)Wtsi/Wtsi

Status

Available to order

EMMA IDEM:12090
International strain nameB6Brd;B6N-Tyrc-Brd Nfkb1tm1a(KOMP)Wtsi/Wtsi
Alternative nameEPD0033_4_D01
Strain typeTargeted Mutant Strains
Allele/Transgene symbolNfkb1tm1a(KOMP)Wtsi,
Gene/Transgene symbolNfkb1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0033_4_D01. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreWellcome Trust Sanger Institute, Hinxton, United Kingdom
Animals used for archivinghomozygous C57BL/6Dnk;C57BL/6Brd-Tyr;C57BL/6N

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • increased leukocyte cell number / IMPC
  • abnormal skin condition / IMPC
  • abnormal cornea morphology / IMPC
  • increased circulating free fatty acid level / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • decreased lean body mass / IMPC
  • increased T cell number / IMPC
  • decreased NK cell number / IMPC
  • increased CD4-positive, alpha beta T cell number / IMPC
  • decreased circulating amylase level / IMPC
  • decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • decreased effector memory CD4-positive, alpha-beta T cell number / IMPC
MGI phenotypes (allele matching)
  • increased leukocyte cell number / MGI
  • lymphoid hyperplasia / MGI
  • decreased IgA level / MGI
  • increased susceptibility to bacterial infection / MGI
  • increased circulating alkaline phosphatase level / MGI
  • decreased regulatory T cell number / MGI
  • decreased NK cell number / MGI
  • decreased IgG1 level / MGI
  • decreased respiratory quotient / MGI
  • increased circulating free fatty acid level / MGI
  • decreased lean body mass / MGI
  • decreased mean corpuscular hemoglobin concentration / MGI
  • decreased circulating amylase level / MGI

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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