B6Dnk;B6Brd;B6N-Tyrc-Brd Mysm1tm1a(KOMP)Wtsi/Wtsi

Status

Available to order

EMMA IDEM:12102
International strain nameB6Dnk;B6Brd;B6N-Tyrc-Brd Mysm1tm1a(KOMP)Wtsi/Wtsi
Alternative nameEPD0019_1_A05
Strain typeTargeted Mutant Strains
Allele/Transgene symbolMysm1tm1a(KOMP)Wtsi,
Gene/Transgene symbolMysm1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0019_1_A05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreWellcome Trust Sanger Institute, Hinxton, United Kingdom
Animals used for archivingheterozygous C57BL/6Dnk;C57BL/6N
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome / Orphanet_508542
IMPC phenotypes (allele matching)
  • mammalian phenotype / IMPC
  • abnormal vertebrae morphology / IMPC
  • abnormal rib morphology / IMPC
  • decreased hematocrit / IMPC
  • decreased leukocyte cell number / IMPC
  • increased granulocyte number / IMPC
  • abnormal coat/ hair morphology / IMPC
  • abnormal cranium morphology / IMPC
  • abnormal hindlimb morphology / IMPC
  • abnormal femur morphology / IMPC
  • abnormal autopod morphology / IMPC
  • kinked tail / IMPC
  • short tail / IMPC
  • tremors / IMPC
  • abnormal body length / IMPC
  • decreased body length / IMPC
  • increased body weight / IMPC
  • decreased body weight / IMPC
  • hyperactivity / IMPC
  • hypoactivity / IMPC
  • abnormal gait / IMPC
  • increased startle reflex / IMPC
  • trunk curl / IMPC
  • decreased caudal vertebrae number / IMPC
  • increased circulating phosphate level / IMPC
  • increased thermal nociceptive threshold / IMPC
  • abnormal coat/hair pigmentation / IMPC
  • abnormal tail morphology / IMPC
  • increased mean corpuscular volume / IMPC
  • increased hematocrit / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased hemoglobin content / IMPC
  • decreased erythrocyte cell number / IMPC
  • abnormal bone mineralization / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased circulating chloride level / IMPC
  • curly tail / IMPC
  • abnormal bone structure / IMPC
  • increased lean body mass / IMPC
  • decreased lean body mass / IMPC
  • abnormal pelvic girdle bone morphology / IMPC
  • abnormal vertebral arch morphology / IMPC
  • vertebral fusion / IMPC
  • abnormal behavior / IMPC
  • increased T cell number / IMPC
  • decreased B cell number / IMPC
  • decreased circulating cholesterol level / IMPC
  • narrow eye opening / IMPC
  • thrombocytosis / IMPC
  • increased hemoglobin content / IMPC
  • decreased circulating total protein level / IMPC
  • increased mean corpuscular hemoglobin concentration / IMPC
  • decreased mature B cell number / IMPC
  • increased IgG2b level / IMPC
  • increased total body fat amount / IMPC
MGI phenotypes (allele matching)
  • belly spot / MGI
  • abnormal hair follicle morphology / MGI
  • distorted hair follicle pattern / MGI
  • abnormal hair cycle / MGI
  • kinked tail / MGI
  • abnormal epidermal layer morphology / MGI
  • abnormal tail morphology / MGI
  • decreased tail pigmentation / MGI

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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