B6Brd;B6N-Tyr^c-Brd Kmt5b^{tm1a(KOMP)Wtsi}/Wtsi

Status	Available to order
EMMA ID	EM:12138
Citation information	RRID:IMSR_EM:12138 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6Brd;B6N-Tyr^c-Brd Kmt5b^{tm1a(KOMP)Wtsi}/Wtsi
Alternative name	EPD0022_2_D02
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Kmt5b^{tm1a(KOMP)Wtsi}
Gene/Transgene symbol	Kmt5b
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0022_2_D02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Wellcome Trust Sanger Institute, Hinxton, United Kingdom
Animals used for archiving	heterozygous C57BL/6Dnk;C57BL/6Brd-Tyr;C57BL/6N males

Disease and phenotype information

IMPC phenotypes (allele matching)

decreased body length / IMPC
decreased body weight / IMPC
abnormal tail movements / IMPC
increased thermal nociceptive threshold / IMPC
increased circulating chloride level / IMPC
decreased total body fat amount / IMPC
decreased bone mineral content / IMPC
preweaning lethality, incomplete penetrance / IMPC
process of degenerative change / IMPC
lipid deposition / IMPC

IMPC phenotypes (gene matching)

decreased body weight / IMPC
decreased bone mineral content / IMPC
preweaning lethality, incomplete penetrance / IMPC
decreased body length / IMPC
process of degenerative change / IMPC
abnormal tail movements / IMPC
lipid deposition / IMPC
increased thermal nociceptive threshold / IMPC
decreased total body fat amount / IMPC
increased circulating chloride level / IMPC

MGI phenotypes (gene matching)

decreased body length / MGI
decreased body weight / MGI
decreased body size / MGI
increased thermal nociceptive threshold / MGI
abnormal pulmonary alveolus morphology / MGI
decreased circulating alanine transaminase level / MGI
decreased lumbar vertebrae number / MGI
decreased total body fat amount / MGI
increased sacral vertebrae number / MGI
neonatal lethality, complete penetrance / MGI
prenatal lethality, incomplete penetrance / MGI

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Availabilities

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Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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