C57BL/6-Dbhtm1a(EUCOMM)Wtsi/Cnbc

Status

Available to order

EMMA IDEM:12233
Citation informationRRID:IMSR_EM:12233 

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International strain nameC57BL/6-Dbhtm1a(EUCOMM)Wtsi/Cnbc
Alternative nameDbhtm1a(EUCOMM)Wtsi
Strain typeTargeted Mutant Strains
Allele/Transgene symbolDbhtm1a(EUCOMM)Wtsi
Gene/Transgene symbolDbh

Information from provider

ProviderMiguel Soares
Provider affiliationBiomedicine, LAIMM - Faculty of Medicine of Porto, Portugal
Genetic informationGene targeted: Dbh (dopamine beta hydroxylase; MGI:94864). Knockout first mice (KOMP tm1a allele; reporter-tagged insertion with conditional potential).
Phenotypic informationHomozygous:
http://www.informatics.jax.org/marker/phenotypes/MGI:94864

Heterozygous:
no abnormal phenotype detected
Breeding history10+ generations. First backcrosses (not with parents but with unrelated C57BL/6J animals), then intercrosses (avoided consanguinity).
ReferencesNone available
Homozygous fertilenot known
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous C57BL/6J males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal heart morphology / MGI
  • decreased body size / MGI
  • blepharoptosis / MGI
  • postnatal growth retardation / MGI
  • absent circulating adrenaline / MGI
  • absent circulating noradrenaline / MGI
  • increased circulating corticosterone level / MGI
  • increased dopamine level / MGI
  • abnormal glucose homeostasis / MGI
  • increased circulating insulin level / MGI
  • postnatal lethality / MGI
  • premature death / MGI
  • no abnormal phenotype detected / MGI
  • decreased circulating glucagon level / MGI
  • decreased glucagon secretion / MGI
  • insulin resistance / MGI
  • abnormal food intake / MGI
  • decreased circulating glucose level / MGI
  • embryonic lethality during organogenesis / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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