IMPC phenotypes (gene matching)
- hypoalgesia / IMPC
B6J.B6N(Cg)-Htr3atm1c(EUCOMM)Wtsi/Cnbc
| Status | Available to order |
| EMMA ID | EM:12234 |
| Citation information | RRID:IMSR_EM:12234 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6J.B6N(Cg)-Htr3atm1c(EUCOMM)Wtsi/Cnbc |
| Alternative name | Htr3a tm1c(EUCOMM)Wtsi ES cell line: JM8A3.N1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Htr3atm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Htr3a |
Information from provider
| Provider | Miguel Soares |
| Provider affiliation | Biomedicine, Faculty of Medicine of the University of Porto |
| Genetic information | Gene targeted: Htr3a (5-hydroxytryptamine (serotonin) receptor 3A; MGI:96282). FLPed knock-out first allele (tm1c) with conditional potential. |
| Phenotypic information | Homozygous:No abnormal phenotype detectedHeterozygous:No abnormal phenotype detected |
| Breeding history | 10+ generations. First backcrosses (not with parents but with unrelated C57BL/6J animals), then intercrosses (avoided consanguinity). |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J males |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased bone marrow cell number / MGI
- hydronephrosis / MGI
- abnormal urinary bladder morphology / MGI
- distended urinary bladder / MGI
- abnormal urinary bladder urothelium morphology / MGI
- abnormal urination pattern / MGI
- kidney inflammation / MGI
- premature death / MGI
- increased urine protein level / MGI
- urinary incontinence / MGI
- prostate gland inflammation / MGI
- decreased lymphocyte cell number / MGI
- cachexia / MGI
- neurogenic bladder / MGI
- increased blood urea nitrogen level / MGI
- increased chemical nociceptive threshold / MGI
- urinary bladder obstruction / MGI
- abnormal urinary bladder physiology / MGI
- pyelonephritis / MGI
- tubulointerstitial nephritis / MGI
- abnormal urinary bladder detrusor smooth muscle morphology / MGI
- abnormal male prostatic urethra morphology / MGI
- abnormal urinary bladder neck morphology / MGI
- increased urinary bladder weight / MGI
- urethra obstruction / MGI
- seminal vesiculitis / MGI