C57BL/6-Tgm3Gt(IST12449B1)Tigm/Cnrm
| Status | Available to order |
| EMMA ID | EM:12275 |
| International strain name | C57BL/6-Tgm3Gt(IST12449B1)Tigm/Cnrm |
| Alternative name | TG3KO - C57Bl6 background |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Tgm3Gt(IST12449B1)Tigm, |
| Gene/Transgene symbol | Tgm3 |
Information from provider
| Provider | Eleonora Candi |
| Provider affiliation | Medicina Sperimentale, Università di Roma Tor Vergata |
| Genetic information | Homozygous Tgm3 gene trap (viable knock out) |
| Phenotypic information | Homozygous:TG3KO mice are viable and fertile. Tgm3 ablation affected partially hair development, no skin formation and gross barrier function defects were observed, but an increased sensitivity to UV photodamage was reported (Frezza V et al, 2017)Heterozygous:None |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Transglutaminase 3 Protects against Photodamage.;Frezza Valentina, Terrinoni Alessandro, Pitolli Consuelo, Mauriello Alessandro, Melino Gerry, Candi Eleonora, ;2017;The Journal of investigative dermatology;137;1590-1594; 28315658