IMPC phenotypes (gene matching)
C57BL/6N-Arap1em1Ciphe/Orl
| Status | Available to order |
| EMMA ID | EM:12426 |
| Citation information | RRID:IMSR_EM:12426 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Arap1em1Ciphe/Orl |
| Alternative name | B6N-Arap1 em1Ciphe |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Arap1em1Ciphe |
| Gene/Transgene symbol | Arap1 |
Information from provider
| Provider | Marie Malissen |
| Provider affiliation | Centre D |
| Genetic information | Mutation in Arap1 gene using CRISPR/Cas9 technology in C57BL/6N eggs. The obtained mutation corresponds to a 222 bp deletion encompassing exon 20 and part of exon 21. The selected mutation was verified by genomic sequencing. |
| Phenotypic information | Homozygous:NAHeterozygous:NA |
| Breeding history | Backcrossed 3 times to C57BL/6N mice. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6N males |
Disease and phenotype information
Literature references
- Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.;Voisinne Guillaume, Kersse Kristof, Chaoui Karima, Lu Liaoxun, Chaix Julie, Zhang Lichen, Goncalves Menoita Marisa, Girard Laura, Ounoughene Youcef, Wang Hui, Burlet-Schiltz Odile, Luche Hervé, Fiore Frédéric, Malissen Marie, Gonzalez de Peredo Anne, Liang Yinming, Roncagalli Romain, Malissen Bernard, ;2019;Nature immunology;20;1530-1541; 31591574