- abnormal vertebrae morphology / IMPC
- abnormal rib morphology / IMPC
- kyphosis / IMPC
- decreased circulating calcium level / IMPC
- increased neutrophil cell number / IMPC
- increased granulocyte number / IMPC
- abnormal cranium morphology / IMPC
- abnormal radius morphology / IMPC
- abnormal tibia morphology / IMPC
- abnormal femur morphology / IMPC
- decreased body length / IMPC
- abnormal cornea morphology / IMPC
- decreased caudal vertebrae number / IMPC
- female infertility / IMPC
- abnormal coat/hair pigmentation / IMPC
- abnormal tail morphology / IMPC
- abnormal fibula morphology / IMPC
- decreased circulating triglyceride level / IMPC
- decreased circulating free fatty acid level / IMPC
- decreased circulating insulin level / IMPC
- decreased erythrocyte cell number / IMPC
- abnormal joint morphology / IMPC
- increased circulating alkaline phosphatase level / IMPC
- thrombocytopenia / IMPC
- abnormal bone structure / IMPC
- increased lean body mass / IMPC
- decreased lean body mass / IMPC
- abnormal spine curvature / IMPC
- abnormal pelvic girdle bone morphology / IMPC
- increased eosinophil cell number / IMPC
- decreased T cell number / IMPC
- abnormal ulna morphology / IMPC
- abnormal zygomatic bone morphology / IMPC
- improved glucose tolerance / IMPC
- abnormal humerus morphology / IMPC
- increased circulating bilirubin level / IMPC
- decreased circulating glucose level / IMPC
- increased mean corpuscular hemoglobin / IMPC
- decreased blood urea nitrogen level / IMPC
- decreased circulating potassium level / IMPC
- increased circulating sodium level / IMPC
- decreased NK T cell number / IMPC
- increased NK cell number / IMPC
- decreased NK cell number / IMPC
- decreased CD4-positive, alpha beta T cell number / IMPC
- increased CD8-positive, alpha-beta T cell number / IMPC
- increased follicular B cell number / IMPC
- decreased germinal center B cell number / IMPC
- decreased gamma-delta T cell number / IMPC
- increased plasmacytoid dendritic cell number / IMPC
- decreased total body fat amount / IMPC
- increased red blood cell distribution width / IMPC
- decreased circulating fructosamine level / IMPC
- abnormal thoracic cage shape / IMPC
- increased bone mineral content / IMPC
- increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
- decreased alpha-beta T cell number / IMPC
- decreased KLRG1-positive NK cell number / IMPC
- increased Ly6C high monocyte number / IMPC
- decreased Ly6C low monocyte number / IMPC
- increased KLRG1+ CD8 alpha beta T cell number / IMPC
- increased memory-marker gamma-delta T cell number / IMPC
- decreased CD5-positive gamma-delta T cell number / IMPC
- increased memory-marker NK cell number / IMPC
- increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
- increased CD8-positive, naive alpha-beta T cell number / IMPC
- increased CD4-negative NK T cell number / IMPC
- decreased memory-marker CD4-negative NK T cell number / IMPC
- increased KLRG1-positive CD4-negative NK T cell number / IMPC
- decreased CD4-positive NK T cell number / IMPC
- decreased memory-marker CD4-positive NK T cell number / IMPC
- decreased Ly6C-positive mature NK cell number / IMPC
- increased Ly6C-positive NK T cell number / IMPC
- decreased early germinal center B cell number / IMPC
- decreased T-helper cell number / IMPC
- decreased effector memory T-helper cell number / IMPC
- increased effector memory T-helper cell number / IMPC
- decreased KLRG1-positive T-helper cell number / IMPC
- increased KLRG1-positive T-helper cell number / IMPC
C57BL/6N-Atm1Brd Sik3tm1a(EUCOMM)Hmgu/WtsiOrl
Status | Available to order |
EMMA ID | EM:12432 |
International strain name | C57BL/6N-Atm1Brd Sik3tm1a(EUCOMM)Hmgu/WtsiOrl |
Alternative name | HEPD0744_6_B02 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Sik3tm1a(EUCOMM)Hmgu, |
Gene/Transgene symbol | Sik3 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from EUCOMM ES clone HEPD0744_6_B02. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
IMPC phenotypes (allele matching)
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).