C57BL/6NTac-Adora2a^em2(IMPC)H/H

Status	Available to order
EMMA ID	EM:12438
Citation information	RRID:IMSR_EM:12438 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Adora2a^em2(IMPC)H/H
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Adora2a^em2(IMPC)H
Gene/Transgene symbol	Adora2a

Information from provider

Provider	MRC, Medical Research Council
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)

increased total body fat amount / IMPC
increased circulating alanine transaminase level / IMPC
decreased hemoglobin content / IMPC
decreased lean body mass / IMPC
increased circulating glucose level / IMPC
decreased lymphocyte cell number / IMPC
decreased locomotor activity / IMPC
increased circulating aspartate transaminase level / IMPC
increased neutrophil cell number / IMPC
increased freezing behavior / IMPC

MGI phenotypes (gene matching)

heart right ventricle hypertrophy / MGI
abnormal pulmonary artery morphology / MGI
increased aggression towards males / MGI
increased anxiety-related response / MGI
hypoactivity / MGI
decreased exploration in new environment / MGI
abnormal liquid preference / MGI
abnormal cardiovascular system physiology / MGI
increased thermal nociceptive threshold / MGI
increased heart rate / MGI
abnormal sclera morphology / MGI
increased systemic arterial blood pressure / MGI
vascular smooth muscle hypertrophy / MGI
hypoalgesia / MGI
myopia / MGI
abnormal locomotor activation / MGI
pulmonary hypertension / MGI
nervous system phenotype / MGI
abnormal lung vasculature morphology / MGI
cardiovascular system phenotype / MGI
vision/eye phenotype / MGI
decreased cerebral infarction size / MGI
decreased susceptibility to ischemic brain injury / MGI
increased body mass index / MGI
decreased interleukin-10 secretion / MGI
decreased physiological sensitivity to xenobiotic / MGI
increased platelet aggregation / MGI
impaired behavioral response to addictive substance / MGI
impaired behavioral response to alcohol / MGI
increased right ventricle systolic pressure / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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