C57BL/6NCrl-Tg(Vav1-STAT5B)731Biat/Biat

Status	Available to order
EMMA ID	EM:12476
International strain name	C57BL/6NCrl-Tg(Vav1-STAT5B)731Biat/Biat
Alternative name	B6N-Tg(STAT5B)731Biat
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Vav1-STAT5B)731Biat
Gene/Transgene symbol	Tg(Vav1-STAT5B)731Biat

Information from provider

Provider	Richard Moriggl
Provider affiliation	Department for Biomedical Sciences, University of Veterinary Medicine, Vienna (Vetmeduni Vienna)
Genetic information	Transgenic mice were generated and bred on a C57BL/6NCrl background. We used the Vav1-hematopoietic vector Vav1-hCD4 (HS21/45) to generate several transgenic mouse lines expressing hSTAT5B and hSTAT5BN642H (EM:12475) in the hematopoietic system and selected the lines B6N-Tg(STAT5B)731Biat (this one, EMMA ID EM:12476) and B6N-Tg(STAT5BN/H)726Biat (EMMA ID EM:12475), respectively, for further experiments. The hSTAT5BN642H construct was generated using overlapping PCR technology.
Phenotypic information	Homozygous: Unknown Heterozygous: No obvious phenotype; therefore the strain is used as a control for strain hSTAT5BN642H (EM:12475).
Breeding history	>10 generations backcrossed
References	STAT5BN642H is a driver mutation for T cell neoplasia.;Pham Ha Thi Thanh, Maurer Barbara, Prchal-Murphy Michaela, Grausenburger Reinhard, Grundschober Eva, Javaheri Tahereh, Nivarthi Harini, Boersma Auke, Kolbe Thomas, Elabd Mohamed, Halbritter Florian, Pencik Jan, Kazemi Zahra, Grebien Florian, Hengstschläger Markus, Kenner Lukas, Kubicek Stefan, Farlik Matthias, Bock Christoph, Valent Peter, Müller Mathias, Rülicke Thomas, Sexl Veronika, Moriggl Richard, ;2018;The Journal of clinical investigation;128;387-401; 29200404
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	University of Veterinary Medicine, Vienna, Austria
Animals used for archiving	heterozygous C57BL/6N

Literature references

STAT5BN642H is a driver mutation for T cell neoplasia.;Pham Ha Thi Thanh, Maurer Barbara, Prchal-Murphy Michaela, Grausenburger Reinhard, Grundschober Eva, Javaheri Tahereh, Nivarthi Harini, Boersma Auke, Kolbe Thomas, Elabd Mohamed, Halbritter Florian, Pencik Jan, Kazemi Zahra, Grebien Florian, Hengstschläger Markus, Kenner Lukas, Kubicek Stefan, Farlik Matthias, Bock Christoph, Valent Peter, Müller Mathias, Rülicke Thomas, Sexl Veronika, Moriggl Richard, ;2018;The Journal of clinical investigation;128;387-401; 29200404

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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