C57BL/6NTac-Prkra^em1(IMPC)H/H

Status	Available to order
EMMA ID	EM:12482
Citation information	RRID:IMSR_EM:12482 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Prkra^em1(IMPC)H/H
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Prkra^em1(IMPC)H
Gene/Transgene symbol	Prkra

Information from provider

Provider	MRC, Medical Research Council
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Dystonia 16 / Orphanet_210571

IMPC phenotypes (allele matching)

male infertility / IMPC
abnormal ear morphology / IMPC
decreased circulating alkaline phosphatase level / IMPC
increased circulating cholesterol level / IMPC
increased blood urea nitrogen level / IMPC
decreased prepulse inhibition / IMPC
increased grip strength / IMPC
increased freezing behavior / IMPC

IMPC phenotypes (gene matching)

decreased circulating alkaline phosphatase level / IMPC
abnormal ear morphology / IMPC
increased grip strength / IMPC
male infertility / IMPC
increased freezing behavior / IMPC
increased blood urea nitrogen level / IMPC
decreased prepulse inhibition / IMPC
increased circulating cholesterol level / IMPC

MGI phenotypes (gene matching)

small ears / MGI
abnormal middle ear morphology / MGI
abnormal neurocranium morphology / MGI
short snout / MGI
decreased body weight / MGI
decreased body size / MGI
postnatal growth retardation / MGI
reduced fertility / MGI
infertility / MGI
female infertility / MGI
abnormal outer ear morphology / MGI
small interparietal bone / MGI
short nasal bone / MGI
turbinate hypoplasia / MGI
abnormal middle ear ossicle morphology / MGI
vision/eye phenotype / MGI
abnormal external auditory canal morphology / MGI
impaired hearing / MGI
embryonic lethality before implantation, complete penetrance / MGI
increased or absent threshold for auditory brainstem response / MGI
wide cranial sutures / MGI
round snout / MGI
small mandibular condyloid process / MGI
abnormal temporal bone zygomatic process morphology / MGI
small mandibular coronoid process / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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