C57BL/6NCrl-Tyrem1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:12496
Citation informationRRID:IMSR_EM:12496 

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International strain nameC57BL/6NCrl-Tyrem1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolTyrem1(IMPC)Ccpcz
Gene/Transgene symbolTyr

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal cell morphology / MGI
  • diluted coat color / MGI
  • irregular coat pigmentation / MGI
  • belly spot / MGI
  • absent hair follicle melanin granules / MGI
  • shiny fur / MGI
  • mottled coat / MGI
  • abnormal retinal photoreceptor morphology / MGI
  • pigmentation phenotype / MGI
  • absent skin pigmentation / MGI
  • abnormal keratinocyte apoptosis / MGI
  • abnormal eye pigmentation / MGI
  • abnormal retina morphology / MGI
  • retinal degeneration / MGI
  • decreased retinal photoreceptor cell number / MGI
  • abnormal coat appearance / MGI
  • male infertility / MGI
  • abnormal coat/hair pigmentation / MGI
  • prenatal lethality / MGI
  • premature death / MGI
  • abnormal vision / MGI
  • abnormal skin pigmentation / MGI
  • no abnormal phenotype detected / MGI
  • no phenotypic analysis / MGI
  • abnormal cell nucleus morphology / MGI
  • failure of zygotic cell division / MGI
  • single kidney / MGI
  • absent seminal vesicle / MGI
  • abnormal chromosome morphology / MGI
  • chromosome breakage / MGI
  • induced chromosome breakage / MGI
  • increased cellular sensitivity to ionizing radiation / MGI
  • abnormal miscarriage rate / MGI
  • abnormal hair follicle melanogenesis / MGI
  • abnormal melanosome morphology / MGI
  • abnormal iris pigmentation / MGI
  • absent coat pigmentation / MGI
  • decreased eye pigmentation / MGI
  • abnormal aqueous drainage system morphology / MGI
  • abnormal retinal ganglion layer morphology / MGI
  • abnormal eye physiology / MGI
  • abnormal intraocular pressure / MGI
  • variegated coat color / MGI
  • homeostasis/metabolism phenotype / MGI
  • reproductive system phenotype / MGI
  • vision/eye phenotype / MGI
  • hypopigmentation / MGI
  • ocular albinism / MGI
  • absent eye pigmentation / MGI
  • decreased survivor rate / MGI
  • transverse fur striping / MGI
  • mortality/aging / MGI
  • abnormal survival / MGI
  • integument phenotype / MGI
  • neonatal lethality, complete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality at implantation, complete penetrance / MGI
  • embryonic lethality before implantation, complete penetrance / MGI
  • decreased ear pigmentation / MGI
  • variegated eye pigmentation pattern / MGI
  • decreased a wave amplitude / MGI
  • decreased b wave amplitude / MGI

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Register interest

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    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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