Cat2ro

Status	Available to order
EMMA ID	EM:12545
International strain name	Cat2ro
Alternative name	Rop; CrygfRop
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Crygf^Rop,
Gene/Transgene symbol	Crygf

Information from provider

Provider	Jana Löster (formerly Kratochvilova)
Provider affiliation	Institut of Mammalian Genetics, Helmholtz Zentrum München
Additional owner	Prof. Dr. Jochen Graw, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Developmental Genetics, Neuherberg/Germany
Genetic information	Semi-dominant mutation in chromosome 1, gene Crygf (T113A; Val38Glu). Mutation generated by Procarbazine. Disclaimer - Special restrictions: 1) Mutant development was phenotype driven. Although for some mutant lines, linkage data and the molecular characterization of the causative mutation has been published, EMMA has not genotyped the strains and can not provide genotyping protocols. 2) Some lines showed low penetrance of the phenotype. 3) Only sperm available. Rederivation service can not be offered. 4) EMMA quality control standards may not apply for these strains. 5) EMMA has not verified the breeding performance and the genetic background of the strains. The genotype/phenotype of the mice is not confirmed by INFRAFRONTIER/EMMA. We strongly recommend that the recipient confirms genotype/phenotype upon receipt.
Phenotypic information	Homozygous: Total cataract Heterozygous: nuclear opacity with radial structures
Breeding history	Kept as homozygotes
References	Dominant cataract and recessive specific-locus mutations detected in offspring of procarbazine-treated male mice.;Kratochvilova J, Favor J, Neuhäuser-Klaus A, ;1988;Mutation research;198;295-301; 3352637 Crygf(Rop): the first mutation in the Crygf gene causing a unique radial lens opacity.;Graw Jochen, Klopp Norman, Neuhäuser-Klaus Angelika, Favor Jack, Löster Jana, ;2002;Investigative ophthalmology & visual science;43;2998-3002; 12202521
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	not known
Immunocompromised	not known

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Literature references

Dominant cataract and recessive specific-locus mutations detected in offspring of procarbazine-treated male mice.;Kratochvilova J, Favor J, Neuhäuser-Klaus A, ;1988;Mutation research;198;295-301; 3352637
Crygf(Rop): the first mutation in the Crygf gene causing a unique radial lens opacity.;Graw Jochen, Klopp Norman, Neuhäuser-Klaus Angelika, Favor Jack, Löster Jana, ;2002;Investigative ophthalmology & visual science;43;2998-3002; 12202521

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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