ADD15306

Status	Available to order
EMMA ID	EM:12557
International strain name	ADD15306
Alternative name	ADD15306
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Cryge^ADD15306,
Gene/Transgene symbol	Cryge

Information from provider

Provider	Paul B. Selby
Provider affiliation	Biology Division, Oak Ridge National Laboratory
Additional owner	Prof. Dr. Jochen Graw, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Developmental Genetics, Neuherberg/Germany
Genetic information	Dominant mutation in chromosome 1, gene Cryge (T134C ; Leu45Pro ). Mutation generated by N-ethyl-N-nitrosourea (ENU) Disclaimer - Special restrictions: 1) Mutant development was phenotype driven. Although for some mutant lines, linkage data and the molecular characterization of the causative mutation has been published, EMMA has not genotyped the strains and can not provide genotyping protocols. 2) Some lines showed low penetrance of the phenotype. 3) Only sperm available. Rederivation service can not be offered. 4) EMMA quality control standards may not apply for these strains. 5) EMMA has not verified the breeding performance and the genetic background of the strains. The genotype/phenotype of the mice is not confirmed by INFRAFRONTIER/EMMA. We strongly recommend that the recipient confirms genotype/phenotype upon receipt.
Phenotypic information	Homozygous: Severe lens opacity and small lens Heterozygous: A dense nuclear and subcortical cataract
Breeding history	kept as homozygotes
References	Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse.;Graw Jochen, Neuhäuser-Klaus Angelika, Klopp Norman, Selby Paul B, Löster Jana, Favor Jack, ;2004;Investigative ophthalmology & visual science;45;1202-13; 15037589
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	not known
Immunocompromised	not known

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Literature references

Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse.;Graw Jochen, Neuhäuser-Klaus Angelika, Klopp Norman, Selby Paul B, Löster Jana, Favor Jack, ;2004;Investigative ophthalmology & visual science;45;1202-13; 15037589

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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