- abnormal auditory brainstem response / IMPC
- decreased prepulse inhibition / IMPC
- decreased startle reflex / IMPC
- abnormal lymph node morphology / IMPC
- abnormal startle reflex / IMPC
- enlarged kidney / IMPC
- abnormal skin morphology / IMPC
- abnormal kidney morphology / IMPC
- abnormal behavior / IMPC
- enlarged lymph nodes / IMPC
- decreased thigmotaxis / IMPC
- decreased anxiety-related response / IMPC
C57BL/6N-Cep85lem1Ciphe/Orl
| Status | Available to order |
| EMMA ID | EM:12612 |
| Citation information | RRID:IMSR_EM:12612 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Cep85lem1Ciphe/Orl |
| Alternative name | Cep85l em1Ciphe |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Cep85lem1Ciphe |
| Gene/Transgene symbol | Cep85l |
Information from provider
| Provider | Marie Malissen |
| Provider affiliation | CIPHE |
| Genetic information | Mutation: complete deletion of exon 1. Mutation in Cep85l gene using CRISPR/Cas technology in C57BL/6N eggs. The obtained mutation corresponds to a 174 bp deletion encompassing exon 1. The selected mutation was verified by genomic sequencing. |
| Phenotypic information | Homozygous:NAHeterozygous:NA |
| Breeding history | Backcrossed 3 times to C57BL/6N mice. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
IMPC phenotypes (gene matching)
Literature references
- Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics.;Voisinne Guillaume, Kersse Kristof, Chaoui Karima, Lu Liaoxun, Chaix Julie, Zhang Lichen, Goncalves Menoita Marisa, Girard Laura, Ounoughene Youcef, Wang Hui, Burlet-Schiltz Odile, Luche Hervé, Fiore Frédéric, Malissen Marie, Gonzalez de Peredo Anne, Liang Yinming, Roncagalli Romain, Malissen Bernard, ;2019;Nature immunology;20;1530-1541; 31591574
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